000			03019cam a2200325 a 4500
003			EG-GiCUC
008			201109s2020 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.08.08.Ph.D.2020.Ma.M
100	0		_aManal Magdy Sayed Hassan
245	1	0	_aModified formulation of some radiolabed anticancer agents for nuclear medicine application / _cManal Magdy Sayed Hassan ; Supervised Mohamed Elnabarawi , Abeer Mohamed Amin , Abdulaziz Mohsen Almahallawi
246	1	5	_aصياغة مطورة لبعض مضادات السرطان المرقمة اشعاعيا لاستخدامها فى تطبيقات الطب النووى
260			_aCairo : _bManal Magdy Sayed Hassan , _c2020
300			_a164 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics
520			_aAs the mortality due to cancer continues to rise, advances in nanotechnology have significantly become an effective approach for achieving efficient drug targeting to tumor tissues. Toxic chemotherapeutics given in their free form distribute broadly throughout the body, but by redirecting more of the drug dose towards tumor sites, reduced systemic side effects are expected, thus making anticancer treatment safer than conventional approaches . A recent interest in the use of self-assembled nanostructured materials for controlling the release of incorporated agents has been evolved. In the pharmaceutical area, viscous lipid-based systems, such as bicontinuous cubic liquid crystalline phases, offer considerable scope for application as drug delivery systems . Nanocubosomes are nano-structures composed mainly of amphiphilic polar lipid. When this amphiphilic substance dissolved in water with concentration above the critical micelle concentration, it forms micellar aggregations. At higher concentrations, the formed micelles are forced to form cubic structure . Alkylating agents, such as chlorambucil (4-[p-[bis [2-chloroethyl] amino] phenyl]-butanoic acid (CHB), are extensively used in the treatment of neoplastic diseases, such as chronic lymphocytic leukemia, lymphomas, advanced ovarian and breast cancer .However, chlorambucil use is limited by its toxic side effects, including myelotoxicity and neurotoxicity. These adverse profiles, limit the use of optimal doses of chemotherapeutic drug CHB. Consequently, protocols with sub-optimal doses are frequently used, minimizing toxicity and patient suffering but often resulting in inefficient treatment and unsatisfactory prognosis
530			_aIssued also as CD
653		4	_a¹²⁵I-Uridine
653		4	_aAnticancer
653		4	_aNanocubosomal
700	0		_aAbdulaziz Mohsen Almahallawi , _eSupervisor
700	0		_aAbeer Mohamed Amin , _eSupervisor
700	0		_aMohamed Elnabarawi , _eSupervisor
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c78651 _d78651