| 000 | 02377cam a2200337 a 4500 | ||
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| 003 | EG-GiCUC | ||
| 005 | 20250223032627.0 | ||
| 008 | 201110s2020 ua d f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.08.05.Ph.D.2020.Me.D | ||
| 100 | 0 | _aMennatallah Ismail Ezz Eldin | |
| 245 | 1 | 0 |
_aDevelopment and validation of different analytical methods for determination of some drugs used for the treatment of GIT diseases / _cMennatallah Ismail Ezz Eldin ; Supervised Marwa Ahmed Fouad , Ramzia Ismail Elbagary |
| 246 | 1 | 5 | _aتطوير و تقييم طرق تحليلية مختلفة لتقدير بعض الأدوية المستخدمة فى علاج أمراض الجهاز الهضمى |
| 260 |
_aCairo : _bMennatallah Ismail Ezz Eldin , _c2020 |
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| 300 |
_a282 P . : _bcharts , facsmilies ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry | ||
| 520 | _aDifferent methods for the determination of some drugs used for the treatment of GIT diseases, in bulk, dosage forms and in rat liver homogenate have been introduced in this thesis. These drugs are aprepitant, fosaprepitant, ondansetron, palonosetron, tropisetron, omeprazole, pantoprazole and ranitidine. Chromatographic part includes UPLC determination of some mixtures namely a binary mixture of ondansetron and omeprazole in pharmaceutical dosage form, a ternary mixture of ondansetron, pantoprazole and ranitidine in two combined dosage forms. In addition, a validated UPLC method was developed for the determination of aprepitant and its prodrug fosaprepitant and applied to an in-vitro activation of prodrug fosaprepitant to the active drug aprepitant using liver S9 fraction. Spectroscopic part includes two quantitative nuclear magnetic resonance spectroscopic (QNMR) methods for the determination of ondansetron (OND) and omeprazole (OMP) in bulk drugs and theirpharmaceutical dosage forms | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aAprepitant | |
| 653 | 4 | _aFosaprepitant | |
| 653 | 4 | _aOndansetron | |
| 700 | 0 |
_aMarwa Ahmed Fouad , _eSupervisor |
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| 700 | 0 |
_aRamzia Ismail Elbagary , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aAmira _eCataloger |
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| 905 |
_aNazla _eRevisor |
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| 942 |
_2ddc _cTH |
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| 999 |
_c78677 _d78677 |
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