000			02987cam a2200349 a 4500
003			EG-GiCUC
005			20250223032638.0
008			201129s2020 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.19.05.M.Sc.2020.As.O
100	0		_aAsmaa Mohammed Elsheshtawy
245	1	0	_aOutcome of pediatric unilateral anaplastic Wilms' Tumor / _cAsmaa Mohammed Elsheshtawy ; Supervised Wael Zekri Khaled , Hisham Mohamed Fahmi , Naglaa AbdelRahim Elkinaai
246	1	5	_aنتائج علاج سرطان الكلى من النوع ويلمزالكشمى أحادى الجانب بالأطفال
260			_aCairo : _bAsmaa Mohammed Elsheshtawy , _c2020
300			_a116 P. : _bcharts , facsmilies ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - National Cancer Institute - Department of Pediatric Oncology
520			_aThis is a retrospective study, for pediatric cases diagnosed as anaplastic Wilms' tumor treated at Children Cancer Hospital Egypt, 57357 (CCHE), from July 2007 to September 2017. All patients were reviewed for demographic profile, clinical features, imaging studies, treatment and outcome. Patients were treated according to modified COG protocol (AREN0321). Patients were followed up till January 2020. The aims of the study: to detect Outcome of anaplastic Wilms' Tumor in pediatric patients and different prognostic factors on outcome (age, stage, diffuse or focal anaplasia) and analysis of chemotherapy related toxicity. In 63 eligiable patients, median age was 4.5 years (range from 9 months to 12.5 years) with slight male predominance 54%. Abdominal mass was the commonest presentation. Twenty patients had metastatic disease 31.7% (n=20 patients), 19 patients had pulmonary metastasis only and one patient had combined pulmonary and hepatic metastases. All patients had anaplastic pathology. Twelve patients had focal anaplasia (19%) and 51 patients had diffuse anaplasia (81%). Stage III disease was the commonest 47.6% followed by stage IV (31.7%). Upfront nephrectomy was done in 18 patients while 45 patients received neoadjuvant chemotherapy.All patients received radiotherapy postoperative, the median time to start radiotherapy after surgery was 27 days. At the end of the study follow up period, five year OS and EFS were 70.7% and 68.1% respectively Recurrent episodes of fever neutropenia and cardiac toxicity were the most common treatment related toxicities among the cases of the study
530			_aIssued also as CD
653		4	_aAnaplastic Wilms' Tumor
653		4	_aChildren Cancer Hospital Egypt, 57357 (CCHE)
653		4	_aWilms' Tumor
700	0		_aHisham Mohamed Fahmi , _eSupervisor
700	0		_aNaglaa AbdelRahim Elkinaai , _eSupervisor
700	0		_aWael Zekri Khaled , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aAmira _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c79020 _d79020