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003			EG-GiCUC
005			20250223032639.0
008			201202s2020 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.12.21.M.Sc.2020.Ei.S
100	0		_aEiman Ismael Mohamed Rayan
245	1	2	_aA study to evaluate the protective effect of green tea catechins against isoniazid-induced hematological and biochemical adverse reactions in rats / _cEiman Ismael Mohamed Rayan ; Supervised Osama Abdelghaffar Youssef
246	1	5	_aدراسة لتقييم التأثير الوقائى لكاتيكينات الشاى الأخضر ضد التفاعلات العكسية الهيماتولوجية والبيوكيميائية الناجمة عن الأيزونيازيد فى الجرذان
260			_aCairo : _bEiman Ismael Mohamed Rayan , _c2020
300			_a225 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology
520			_aThe aim of this study was to evaluate the protective role of the green tea catechins (GTC) against the isoniazid (INH)-induced oxidative stress and associated hematological and biochemical alterations in rats. One hundred male albino rats were divided into four groups: (i) control, (ii) INH-treated, (iii) (INH+GTC)-treated and (iv) GTC-treated groups. In the 2nd and 3rd groups, INH was orally administered at a dose level of 27 mg/kg b.wt., which was equivalent to the therapeutic dose of humans, daily for five weeks. In the 3rd group, GTC were orally administered at a dose level of 50 mg/kg b. wt. one hour prior to INH administration, daily for five weeks. In the 4th group, GTC were orally administered to the animals daily for five weeks at dose level of 50 mg/kg b. wt. From each group, five animals were weekly taken out for sampling of blood and liver.The administration of INH resulted in a normocytic normochromic anemia and leukopenia. Leukopenia was a direct consequence of the reduction in absolute counts of neutrophils, eosinophils, lymphocytes and monocytes. In INH-treated rats, significant increments were observed in serum total cholesterol, LDL-cholesterol, atherosclerotic indices and triglyceride levels whereas HDL-cholesterol level was decreased. Serum total protein and albumin levels were reduced whereas serum globulin level was slightly increased. Serum urea and creatinine levels were not altered in INH-treated rats. Liver function markers (ASAT, ALAT, ALP, total and direct bilirubin) were elevated by the INH administration being indicative to the hepatic damage. Lipid peroxidation was evidenced through the increased level of liver malondialdehyde (MDA) concentrations. The endogenous antioxidant system showed noticeable decrements in liver glutathione (GSH) content and the activities of liver superoxide dismutase (SOD) and catalase (CAT) and erythrocyte glucose-6-phosphate dehydrogenase (G6PD
530			_aIssued also as CD
653		4	_aAnti-TB drugs
653		4	_aIsoniazid
653		4	_aOxidative stress
700	0		_aOsama Abdelghaffar Youssef , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c79054 _d79054