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| 003 | EG-GiCUC | ||
| 005 | 20250223032640.0 | ||
| 008 | 201205s2020 ua h f m 000 0 eng d | ||
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_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.08.05.Ph.D.2020.No.D | ||
| 100 | 0 | _aNoura Sayed Hanafy Mahmoud | |
| 245 | 1 | 0 |
_aDesign, synthesis and biological evaluation of some new barbituric acid derivatives with anticipated anticancer activity / _cNoura Sayed Hanafy Mahmoud ; Supervised Samir Mohamed Elmoghazy , Riham Francois George , Essam Eldin Abdelfattah Osman |
| 246 | 1 | 5 | _aتصميم: تشييد وتقييم بيولوجى لبعض مشتقات حمض الباربيتيوريك الجديدة ذات نشاط متوقع كمضادات للسرطان |
| 260 |
_aCairo : _bNoura Sayed Hanafy Mahmoud , _c2020 |
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| 300 |
_a100 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry | ||
| 520 | _aThis work deals with the design and synthesis of some novel pyrimidinone derivatives; Va-e, VIa-e, VIIa-e, Xa-d, XIa-d and XIIa-d as PARP-1 inhibitors. Molecular modeling techniques were used to support the design.The twenty seven newly synthesized compounds were evaluated for their ability to inhibit PARP-1.The in vitro cytotoxic activity of the target compounds was also performed at National Cancer Institute, NCI, Maryland, USA against sixty cell lines.The most active compounds against PARP1 in vitro were evaluated in the BRCA1 mutated breast cancer cell line MDA-MB-436 | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aMolecular docking | |
| 653 | 4 | _aPARP-1 inhibitors | |
| 653 | 4 | _aPyrimidinones | |
| 700 | 0 |
_aEssam Eldin Abdelfattah Osman , _eSupervisor |
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| 700 | 0 |
_aRiham Francois George , _eSupervisor |
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| 700 | 0 |
_aSamir Mohamed Elmoghazy , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
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_aNazla _eRevisor |
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_aShimaa _eCataloger |
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| 942 |
_2ddc _cTH |
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_c79098 _d79098 |
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