| 000 | 03233cam a2200337 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223032640.0 | ||
| 008 | 201205s2020 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.08.01.Ph.D.2020.Sh.A | ||
| 100 | 0 | _aShams Gamal Eldin Amin Shams | |
| 245 | 1 | 0 |
_aAmelioration of copper oxide nanoparticles-induced oxidative stress by dehydroepiandrosterone either alone or in combination with Quercetin on rat liver : _bIn vitro and in vivo study / _cShams Gamal Eldin Amin Shams ; Supervised Samy Abdelfatah Abdelazim , Hanan Farouk Aly |
| 246 | 1 | 5 |
_aتحسين التوتر التأكسدى الناجم عن جسيمات اوكسيد النحاس النانويه بواسطة الديهيدروابيندروستيرون على حدة او مقترنا مع الكيرستين فى كبد الجرذان : _bدراسة معملية وفي داخل الجسم الحى |
| 260 |
_aCairo : _bShams Gamal Eldin Amin Shams , _c2020 |
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| 300 |
_a136 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry | ||
| 520 | _aThe present study aimed to clarify the effect of Copper oxide nanoparticles (CuO NPs) on hepatocellular carcinoma HepG2 cells in vitro and on normal rat liver in vivo. In addition, evaluation of the therapeutic efficacy of individual or combined doses of dehydro-epiandrosterone (DHEA) and quercetin in ameliorating some biochemical indices in liver of CuO NPs intoxicated-rats. CuO NPs (50nm) was administered at a dose of 100 mg/Kg for two weeks to rats followed by the fore-mentioned antioxidants for 3 weeks. In the present study, we highlighted the therapeutic effect of DHEA and/or quercetin against CuO NPs toxicity through monitoring the alteration of liver enzyme markers, antioxidant defense mechanism, necrosis, apoptosis, hepatic histopathological alterations, and DNA damage.The rats given CuO NPs only showed marked significant elevation in liver enzymes, alteration in oxidant-antioxidant balance and an elevation in the hepatic inflammatory marker; tumor necrosis factor-Ü (TNF-Ü). Additionally, over expression of both caspase-3 and Bcl2 associated X protein were detected. Whereas, B-cell lymphoma-2 was down regulated and DNA fragmentation was elevated. Moreover, histopathological examination of hepatic tissue reinforced the previous biochemical results.Treatment with either DHEA, quercetin alone or in combination ameliorated the deviated parameters against CuO NPs toxicity in rat with variable degrees.In conclusion, our findings suggest that the fore-mentioned treatments exert therapeutic effect in CuO NPs toxicity by diminishing oxidative stress, mRNA gene expression and hepatic tissues DNA damage | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aApoptosis | |
| 653 | 4 | _aCopper oxide nanoparticles | |
| 653 | 4 | _aDehydroepiandroestrone | |
| 700 | 0 |
_aHanan Farouk Aly , _eSupervisor |
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| 700 | 0 |
_aSamy Abdelfatah Abdelazim , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
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| 905 |
_aShimaa _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c79099 _d79099 |
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