000			03060cam a2200349 a 4500
003			EG-GiCUC
005			20250223032645.0
008			201219s2020 ua f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.12.10.M.Sc.2020.Ya.S
100	0		_aYara Nour Eldin Mohamed Laboud
245	1	0	_aSynthesis of some fused heterocyclic compounds incorporating isoquinoline moiety with expected biological activity / _cYara Nour Eldin Mohamed Laboud ; Supervised Hyam A. Abdelhadi , Mohamed A. Mohamed Teleb , Fatma M. Saleh
246	1	5	_aتحضير بعض المركبات الملتحمة غير متجانسة الحلقة متضمنة جزئية الأيزوكينولين و المتوقع لها نشاط بيولوجى
260			_aCairo : _bYara Nour Eldin Mohamed Laboud , _c2020
300			_a98 P. ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry
520			_aThe present dissertation describes the utility of isoquinoline derivatives in the synthesis of new heterocyclic compounds by treatment of 2-(6,7-dimethoxy-3,4-dihydroisoquinolin-1- yl)acetonitrile 1 with arylisothiocycnates 2a-c in refluxing toluene to afford thioanilide derivatives 3, which converted to the corresponding thiadiazole derivatives 5A-P upon refluxing with Ü-ketohydrazonoyl halides 4A-P in chloroform in the presence of triethylamine. Refluxing of thiadiazoles 5A-C with N,N-dimethylformamide dimethylacetal afforded enaminones 11A-C. Also, study the Michael addition reaction of enaminones 14a-d with compound 1 in refluxing ethanol in the presence of piperidine to yield 4H-pyrido[2,1-a]isoquinoline-1-carbonitrile derivatives 16a-d. Also, reaction of and ethyl 3-aryl-2-cyanoacrylate 19a-g with compound 1 under the same previous conditions, using acetonitrile instead of ethanol, gave 4H-pyrido[2,1- a]isoquinoline-1,3-dicarbonitrile derivatives 23a-g. Stirring of aldehydes 24a-i with 1 in absolute ethanol in the presence of concentrated hydrochloric acid gave the corresponding arylidene derivatives 25, which converted to 5,6-dihydropyrrolo[2,1-a]isoquinoline-1-carbonitrile derivatives 28a-g by refluxing with Ü-ketohydrazonoyl halides 4A,G,K in chloroform in the presence of triethylamine. The structures of the new heterocyclic compounds prepared were established on the basis of elemental analysis and spectral analyses (IR, ¹H NMR, ¹³C NMR, MS). Also, some of the new compounds were tested for their antibacterial and antifungal activities
530			_aIssued also as CD
653		4	_a2-(6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)acetonitrile
653		4	_aThiadiazole
653		4	_aÜ- ketohydrazonoyl halide
700	0		_aFatma M. Saleh , _eSupervisor
700	0		_aHyam A. Abdelhadi , _eSupervisor
700	0		_aMohamed A. Mohamed Teleb , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c79265 _d79265