000			03286cam a2200349 a 4500
003			EG-GiCUC
005			20250223032646.0
008			201223s2020 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.21.M.Sc.2020.Sa.R
100	0		_aSara Refaat Shazly
245	1	0	_aRelation of serum level of tumor necrosis factor {u2013} alpha to cognitive functions in patients with parkinson{u2019}s disease / _cSara Refaat Shazly ; Supervised Manal Mahmoud Elkattan , Rania Shehata Mohamed , Laila Ahmed Rashed
246	1	5	_aعلاقة مستوى معامل نخر الورم {u٢٠١٣} ألفا فى الدم بالوظائف المعرفيه فى مرضى داء باركنسون
260			_aCairo : _bSara Refaat Shazly , _c2020
300			_a122 P. : _bcharts , facimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Neuropsychiatry
520			_aBackground: Parkinson{u2019}s disease (PD) is a common, disabling, neurodegenerative disorder. In addition to classical motor symptoms, non-motor features are now widely accepted as part of the clinical picture, and cognitive decline is a very important aspect of the disease. However, at present, the pathophysiology and clinical management of these symptoms are poorly understood. Objectives: The present study aimed to investigate the association between serum TNF-Ü level and cognition in PD patients, and to examine their relation to clinical presentation and disease severity. Methods: Thirty diagnosed PD patients and thirty healthy controls were included in this study. Patients were subjected to complete clinical assessment and Unified Parkinson Disease Rating Scale (UPDRS) was done to evaluate severity of PD. Cognitive assessment using Addenbrooke{u2019}s Cognitive Examination (ACE-III) and trail making B test and measurement of serum levels of TNF-Ü were done for both patients and controls. Results: The patients showed significant worse performance than controls in the cognitive assessment scales except for language subset of ACE score.Mean serum TNF-Ü level was significantly higher in PD patients compared to controls.TNF-Ü serum level was significantly negatively correlated with ACE language but not with age, age at onset, duration of the disease, UPDRS and H&Y scores. Sensitivity and specificity of TNF-Ü to detect cognitive impairment in PD using ACE III and trail making B were (73.1, 75%), (57.1, 56.2 %) respectively .Whereas, sensitivity and specificity of TNF-Ü to detect severity of PD using H&Y staging in PD were 50%. Conclusion: cognitive impairment is commonly encountered in PD patients. Elevated serum levels of TNF-Ü in PD patients implicate this proinflammatory cytokine in the pathophysiology of the disease
530			_aIssued also as CD
653		4	_aACE-III
653		4	_aCognitive functions
653		4	_aParkinson{u2019}s disease
700	0		_aLaila Ahmed Rashed , _eSupervisor
700	0		_aManal Mahmoud Elkattan , _eSupervisor
700	0		_aRania Shehata Mohamed , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c79291 _d79291