| 000 | 02820cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223032651.0 | ||
| 008 | 210103s2020 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.12.25.M.Sc.2020.Ay.M | ||
| 100 | 0 | _aAya Osama Fekry Ibrahim Khamis | |
| 245 | 1 | 0 |
_aMetaproteomics study of autism spectral disorder in pediatric patients : _bpotential clinical impact / _cAya Osama Fekry Ibrahim Khamis ; Supervised Ismail Abdelshafy Abdelhamid , Sherif Abdelaziz Ibrahim , Sameh Magdeldin Mohamed |
| 246 | 1 | 5 |
_aالآثار السريرية المحتملة : _bدراسة الميتابروتيومكس الخاص بالأطفال المرضى بالتوحد |
| 260 |
_aCairo : _bAya Osama Fekry Ibrahim Khamis , _c2020 |
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| 300 |
_a116 P . : _bcharts , facsmilies ; _c25cm |
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| 502 | _aThesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biotechnology | ||
| 520 | _aASD (Autism Spectrum Disorder) is a class of neurodevelopmental disorders that affects communication and behavior. The prevalence of these pervasive disorders has been estimated to be as high as 1 in every 45 individuals. Gastrointestinal (GI) symptoms are common disorders associated with ASD patients, however, the underlying mechanisms are still unknown. Many studies have shown alterations in the composition of the fecal flora of the gut microbiome in patients with ASD. The gut microbiota has been proposed to influences brain development and behaviors through the neuroendocrine, neuroimmune, and autonomic nervous systems. Additionally, abnormal gut microbiota was reported to be associated with several diseases, such as inflammatory bowel disease (IBD), ASD, and mood disorders. Recent research proposed that toxins produced by abnormal gut bacteria may trigger or worsen autism in some children. It is thought that these molecular signals largely originate from the microbiome and they play a crucial role in basic neurodegenerative processes such as affecting the permeability of blood-brain-barrier, myelination, neurogenesis, microglia maturation, and also modulates many aspects of animal behavior. Thus, focused analysis on the metaproteome of ASD patients together with host proteome interaction will provide new insights in understanding the role of the gut microbiota in the ASD | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aASD | |
| 653 | 4 | _aMetaproteome | |
| 653 | 4 | _aMicrobiota | |
| 700 | 0 |
_aIsmail Abdelshafy Abdelhamid , _eSupervisor |
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| 700 | 0 |
_aSameh Magdeldin Mohamed , _eSupervisor |
|
| 700 | 0 |
_aSherif Abdelaziz Ibrahim , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aAmira _eCataloger |
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| 905 |
_aNazla _eRevisor |
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| 942 |
_2ddc _cTH |
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| 999 |
_c79437 _d79437 |
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