000			03550cam a2200325 a 4500
003			EG-GiCUC
008			210123s2020 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.08.07.Ph.D.2020.Ne.P
100	0		_aNehal Sameh Mohammed Ramadan
245	1	0	_aPhytochemical and biological investigation of averrhoa carambola L. (Family : Oxalidaceae) cultivated in Egypt / _cNehal Sameh Mohammed Ramadan ; Supervised Mohamed Ali Ali Farag , Nabil Hussein Elsayed Khamis , Zeinab Kandil
246	1	5	_aدراسة فيتوكيميائية و بيولوجية لنبات برتقال البامية (العائلة الحماضية) المزروع فى مصر
260			_aCairo : _bNehal Sameh Mohammed Ramadan , _c2020
300			_a314 P. : _bcharts , facimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacognosy
520			_aAverrhoa carambola L. is a tropical tree with edible fruits that grows at different climatic conditions. Despite its nutritive value and reported health benefits, it is a controversial plant owing to its fruits rich oxalate content.The present study aimed at investigating aroma and nutrient primary metabolites distribution in A. carambola fruits grown in Indonesia, Malaysia (its endemic origin) versus Egypt, and at different ripening stages.Two techniques were employed to assess for volatile and non-volatile metabolites including headspace solid-phase micro-extraction (HS-SPME) coupled to gas chromatography mass-spectrometry (GC-MS) and GC-MS post silylation, respectively. 24Volatiles were detected, with esters amounting for the major class in Egyptian fruits at ca. 66%, with methyl caproate as the major component. Primary metabolites profiling led to the identification of 117 metabolites viz. sugars, polyols and organic acids. Fructose (38{u2013}48%) and glucose (21{u2013}25%) predominated sugar compositions in ripe fruits, whereas sorbitol was the major sugar alcohol (2.4{u2013}10.5%) in ripe fruits as well. Oxalic acid, an anti-nutrient with potential health risks, was the major organic acid detected in all fruits (1.7{u2013}2.7%), except the Malaysian one (0.07%). Further objective of this study was to investigate the use of its plant parts (leaves & fruits) cultivated in Egypt forthe treatment of obesity as extracts and its isolated compounds.The effect of the total MeOHextracts of leaf and fruit on high-fat diet induced obesity in rats was evaluated in vivo. Results revealed thatboth extracts exhibited potential anti-obese activity in comparison to Orly as a reference drug. To pinpoint for the active agents in A. carambolaleaf extract cultivated in Egypt as an anti-obese and antidiabetic agents,a detailed phytochemical study was adopted. 14 compounds were isolated including 3 new dihydrochalcone glycosides & 1 flavonoid glycoside. The isolated compounds were comparatively assessed for their antidiabetic and cytotoxic activities. Structure-activity relationship (SAR) was adopted to determine the effect of substitution pattern on biological effects
530			_aIssued also as CD
653		4	_aA. carambola
653		4	_aAnti-obesity
653		4	_aCytotoxicity
700	0		_aMohamed Ali Ali Farag , _eSupervisor
700	0		_aNabil Hussein Elsayed Khamis , _eSupervisor
700	0		_aZeinab Kandil , _eSupervisor
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c79652 _d79652