| 000 | 03058cam a2200325 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 008 | 210131s2020 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.11.02.Ph.D.2020.He.T | ||
| 100 | 0 | _aHend Ahmed Abdallah Badawi | |
| 245 | 1 | 0 |
_aTherapeutic role of stem cells versus curcumin nanoemulsion on cadmium induced acute testicular damage in adult albino rats : _bHistological, immunohistochemical and biochemical study / _cHend Ahmed Abdallah Badawi ; Supervised Hany Abdellatif Soliman , Shereen Abdelfattah Mahamed , Rasha Abdelkhalek Attia Radwan |
| 246 | 1 | 5 |
_aالدور العلاجى للخلايا الجذعية مقارنة بجزيئات الكركم متناهية الصغر على التلف الحاد للخصية فى الفار الابيض البالغ الناتج عن الكادميوم : _bدراسة هستولوجية وهستوكيميائية مناعية وكيميائية |
| 260 |
_aCairo : _bHend Ahmed Abdallah Badawi , _c2020 |
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| 300 |
_a154 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Anatomy | ||
| 520 | _aCadmium (Cd), a grave occupational pollutant, can result in; testicular damage. This study was designed to distinguish the potential effect of bone marrow-derived mesenchymal stem cells (BM-MSCs) versus that of curcumin nanoemulsion on Cdinduced testicular damage. Fifty adult male Sprague Dawley rats were distributed into five groups; control, sham control, Cd-treated, stem cell-treated and nanocurcumintreated groups. Histological, immune histochemical; caspase 3 and proliferating cell nuclear antigen (PCNA),testosterone levels, nitric oxide, malondialdehyde (MDA)/glutathione (GSH) superoxide, dismutase (SOD), Western blot; B-cell lymphoma (Bcl-2), BCL2-Associated X Protein (BAX), BAX/Bcl-2 ratio and morphometry were done. Cadmium-treated group showed degenerated, detached seminiferous tubules, vacuolations and wide interstitial spaces containing fluid exudates.The same group revealed increased expression of BAX, BAX/Bcl-2 ratio, caspase 3and increased mean values of MDA, NO. Concomitantly, Cd has significant reduction in PCNA, Bcl-2 and sperm cell count when compared to control group. BM-MSCs- and nanocurcumin-treated groups revealed well-structured tubules and were perceived to expressively enhance the deleterious changes induced by Cd. The injurious changes on the testis induced by Cd were obviously improved when treated with either MSCs or nano-curcumin. BM-MSCs exerted more ameliorative changes | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aCadmium | |
| 653 | 4 | _aMesenchymal stem cells | |
| 653 | 4 | _aNanocurcumin | |
| 700 | 0 |
_aHany Abdellatif Soliman , _eSupervisor |
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| 700 | 0 |
_aRasha Abdelkhalek Attia Radwan , _eSupervisor |
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| 700 | 0 |
_aShereen Abdelfattah Mahamed , _eSupervisor |
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| 905 |
_aNazla _eRevisor |
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| 905 |
_aShimaa _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c79781 _d79781 |
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