| 000 | 03082cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223032703.0 | ||
| 008 | 210207s2020 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
||
| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.08.09.Ph.D.2020.Om.P | ||
| 100 | 0 | _aOmnia Farouk Abdelmonem Hassan | |
| 245 | 1 | 0 |
_aPossible beneficial effects of benfotiamine, a thiamine derivative, in isoproterenol-induced myocardial infarction in rats / _cOmnia Farouk Abdelmonem Hassan ; Supervised Aiman Saad Elkhatib , Lamiaa Ahmed Ahmed , Omneya Osama Galal |
| 246 | 1 | 5 | _aالدور المفيد المحتمل للبنفوتيامين: مشتق الثيامين: فى علاج إحتشاء عضلة القلب الناجم عن إيزوبروتيرينول فى الجرذان |
| 260 |
_aCairo : _bOmnia Farouk Abdelmonem Hassan , _c2020 |
||
| 300 |
_a134 P. : _bcharts , facimiles ; _c25cm |
||
| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology | ||
| 520 | _aAcute myocardial infarction (AMI) remains the most common cause of morbidity and mortality worldwide.The present study was directed to investigate the beneficial effects of pre- and post-treatments with benfotiamine in isoproterenol (ISO)-induced MI in rats. Myocardial heart damage was induced by subcutaneous injection of ISO (150 mg/kg) once daily for two consecutive days. Benfotiamine (100 mg/kg/day) was given orally for two weeks before or after ISO treatment. ISO administration revealed significant changes in electrocardiographic recordings, elevation of levels of cardiac enzymes; creatinine kinase (CK-MB) and troponin-I (cTn-I), and perturbation of markers of oxidative stress; nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD) and glutathione peroxidase (GPx) and markers of inflammation; protein kinase C (PKC), nuclear factor-kappa B (NF-{uF06B}B) and metalloproteinase-9 (MMP-9).The apoptotic markers (caspase-8 and p53) were also significantly elevated in ISO groups in addition to histological alterations. Groups treated with benfotiamine pre- and post-ISO administration showed significant decrease in cardiac enzymes levels and improvement of oxidative stress, inflammatory and apoptotic markers compared to the ISO groups. The current study highlights the potential role of benfotiamine as a promising agent for prophylactic and therapeutic interventions in myocardial damage in several cardiovascular disorders via NADPH oxidase inhibition | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aAcute myocardial infarction (AMI) | |
| 653 | 4 | _aCreatinine kinase (CK-MB) | |
| 653 | 4 | _aisoproterenol (ISO) | |
| 700 | 0 |
_aAiman Saad Elkhatib , _eSupervisor |
|
| 700 | 0 |
_aLamiaa Ahmed Ahmed , _eSupervisor |
|
| 700 | 0 |
_aOmneya Osama Galal , _eSupervisor |
|
| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
||
| 905 |
_aShimaa _eCataloger |
||
| 942 |
_2ddc _cTH |
||
| 999 |
_c79825 _d79825 |
||