000			02934cam a2200349 a 4500
003			EG-GiCUC
005			20250223032703.0
008			210208s2020 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.19.05.M.Sc.2020.Sa.O
100	0		_aSafaa AbdElhafeez Khaled
245	1	0	_aOutcome of pediatric patients with extracranial germ cell tumor, a single institutional experience, Egypt / _cSafaa AbdElhafeez Khaled ; Supervised Lobna M. Elamin Shalaby , Sahar Ahmed Khalil , Nesreen Magdy Mahmoud
246	1	5	_aنتائج علاج الاطفال المرض باورام الخلايا الجرثىمية خارج المخ بالمعهد القومي للأورام ، تجربة مؤسسة واحدة، مصر
260			_aCairo : _bSafaa AbdElhafeez Khaled , _c2020
300			_a158 P. : _bcharts , facimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - National Cancer Institute - Department of Pediatric Oncology
520			_aIntroduction: Extracranial germ cell tumors are categorized as rare pediatric tumors. Childhood germ cell tumors (GCTs) are an assorted group of malignant and benign neoplasms that vary with respect to their clinical presentation, histopathology, and biologic characteristics, but are all believed to originate from primordial germ cells. Patient and methods: Among fifty eight eligible patients with extracranial germ cell tumor enroled from June 2011 to June 2017 who were treated according to Children{u2019}s Oncology Group (COG) protocol AGCT0132 which divided pediatric patients with germ cell tumors into three categories: low, intermediate, and high risk groups. Results: The 3- years overall survival (OS) was 86.2% with a median follow up period of 38.3 months (range from 0.3-96.7months) and 3-years event free survival (EFS) was 82.8% with median 36.1months (range from 0.1- 94.8months). The independent factor that significantly affect the overall survival was site of the primary [(gonadal vs extragonadal) (HR: 14.481, 95% CI: 1.761-119.063, p= 0. 013)] and pathological subtypes [(teratoma vs others) (HR: 8.210, 95% CI: 1.001-67.365, p=0.049)] and the independent factor that significantly affect the event-free survival were site of the primary [(gonadal vs extragonadal) (HR: 3.979, 95% CI: 1.027-15.406, p= 0. 046)] and pathological subtypes [(teratoma vs others) (HR: 6.508, 95% CI: 1.155-53.486, p=0.036)]
530			_aIssued also as CD
653		4	_aAFP
653		4	_aExtracranial germ cell tumors
653		4	_aGonadal &extragonadal tumorplatinum based therapy
700	0		_aLobna Mohamed Elamin Shalaby , _eSupervisor
700	0		_aNesreen Magdy Mahmoud , _eSupervisor
700	0		_aSahar Ahmed Khalil , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c79856 _d79856