| 000 | 03420cam a2200349 a 4500 | ||
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| 003 | EG-GiCUC | ||
| 005 | 20250223032709.0 | ||
| 008 | 210228s2020 ua dh f m 000 0 eng d | ||
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_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.11.30.Ph.D.2020.Do.S | ||
| 100 | 0 | _aDoaa Mostafa Elsayed | |
| 245 | 1 | 0 |
_aStudy on effect of dipeptidyl peptidase (DPP)-IV inhibitor on renal functions in rhabdomyolysis induced acute renal injury in rats / _cDoaa Mostafa Elsayed ; Supervised Samah Elattar , Nashwa Eltablawy , Shaimaa Nasr Amin |
| 246 | 1 | 5 | _aدراسه عن تاثير مثبطات انزيم ثنائى البيبتيد الرابع على وظائف الكلى فى حالات الاصابه الحادة للكلى الناتجه عن انحلال العضلات المخططه فى الجرذان |
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_aCairo : _bDoaa Mostafa Elsayed , _c2020 |
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_a303 P. : _bcharts , facimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Physiology | ||
| 520 | _aBackground: Acute kidney injury (AKI) is a kind of acute dysfunction of the kidneys caused by various reasons in a short term, which usually leads to a serious disorder of the body{u2019}s internal environment. Rhabdomyolysis (RM) is considered to be one of the leading causes of AKI. Glycerol induced AKI is well-established animal model of rhabdomyolysis. There is accumulating evidence to suggest the potential benefits of DPP-IV inhibitor is in the setting of AKI. Aim of the work: Our study was designed to study the possible role of dipeptidyl peptidase DPP-IV inhibitor in modulating the pathogenic events related to rhabdomyolysis induced AKI in rats. It also compared between DPP-IV inhibitor and saline as the conventional treatment of AKI concerning their protective effects on AKI when used either separately or in combination and when used for different time intervals of the experiment (24 h and 72 h after injection of glycerol). Methods: Eighty male Albino rats were divided into 5 groups Group I: (control group), Group II; (AKI group), Group III;(AKI+ saline), Group IV;(AKI +sitagliptin 600 mg/kg/day), Group V; (AKI +sitagliptin+ saline), all groups of rats except the control group injected by 50% glycerol (10 ml/kg, i.m.) half dose in each hind limb muscle to induce AKI. All groups were divided into sub groups 8 rats each. Rat tail systolic blood pressure was measured either 24 h or 72 h after glycerol injection. Urine was collected separately for each rat, for 24 h for measurement of urine volume and urinary creatinine levels and GFR calculation. Blood samples were withdrawn retro-orbitally either at 24 h or 72 h after glycerol injection for measuring of serum creatinine, blood urea nitrogen, Na+, K+, creatine phosphokinase (CPK), Glucagon like peptide 1 (GLP1), TNF Ü, interleukin 10. Then 8 rats from each group were sacrificed either at 24 or72hours after injection of glycero | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _a glycerol induced AKI | |
| 653 | 4 | _aAcute kidney injury | |
| 653 | 4 | _aRhabdomyolysis | |
| 700 | 0 |
_aNashwa Eltablawy , _eSupervisor |
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| 700 | 0 |
_aSamah Elattar , _eSupervisor |
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| 700 | 0 |
_aShaimaa Nasr Amin , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
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_aNazla _eRevisor |
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_aShimaa _eCataloger |
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_2ddc _cTH |
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_c80047 _d80047 |
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