000			02876cam a2200325 a 4500
003			EG-GiCUC
008			210315s2020 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.11.01.Ph.D.2020.Mo.E
100	0		_aMohammad Ahmad Saleh Bashar
245	1	0	_aEvaluating the effect of desflurane versus sevoflurane withrecent biomarkers of renal and hepatic function in laparoscopic cholecystecomy patients / _cMohammad Ahmad Saleh Bashar ; Supervised Mohamed Hafez Elsaied Hafez , Sohaila Hussein Omar , Azza Saleh Radwan
246	1	5	_aتحديثات فى تقييم أثر الديسفلورين والسيفوفلورين على وظائف الكبد والكلى فى مرضى استئصال المرارة بالمنظار
260			_aCairo : _bMohammad Ahmad Saleh Bashar , _c2020
300			_a141 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Anaesthesia
520			_aBackground: Exposure to inhalational anesthetics is associated with hepatic and renal changes. aim: To compare sevoflurane (S) versus desflurane (D) with more sensitive and specific biomarkers of hepatic and renal functions in patients undergoing elective laparoscopic cholecystectomy. patients and methods: A prospective randomized study with 70 patients (D, n = 35 and S, n = 35). Neutrophil Gelatinase Associated Lipocalin, Cystatin-C, Arginase, liver (AST, ALT) and kidney function tests (BUN and creatinine) were assayed.results: High serum NGAL levels suggest the possibility of subclinical renal injury in the desflurane group, but with no renal clinical adverse effects.The specific biomarkers showed early elevations at 1 hour postoperatively for cystatin and 1 to 6 hours postoperatively with arginase in both groups, with no adverse clinical renal or liver effects. conclusion:This study confirmed that sevoflurane and desflurane provide safe anesthetic profiles regarding renal and hepatic integrity during limited duration laparoscopic procedures. Sevoflurane and desflurane had no adverse clinical effects in these patients undergoing laparoscopic cholecystecomy. Wide scale studies comprising larger numbers of patients should be performed to assess the microscopic effects on hepatic and renal integrity using sevoflurane and desflurane during longer periods of exposure to pneumoperitoneum and volatile anesthetics
530			_aIssued also as CD
653		4	_aDesflurane
653		4	_aLaparoscopic cholecystecomy patients
653		4	_aSevoflurane
700	0		_aAzza Saleh Radwan , _eSupervisor
700	0		_aMohamed Hafez Elsaied Hafez , _eSupervisor
700	0		_aSohaila Hussein Omar , _eSupervisor
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c80253 _d80253