000			03344cam a2200325 a 4500
003			EG-GiCUC
008			210327s2020 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.12.21.Ph.D.2020.Ay.A
100	0		_aAya Abdelnasser Mahmoud
245	1	0	_aAssessment of teratogenic and genotoxic effects of insecticide lufenuron on pregnant albino rats and their fetuses / _cAya Abdelnasser Mahmoud ; Supervised Abdelrahman Tawfik , Amel Ramadan Omar , Wesam Taha Basal
246	1	5	_aتقييم آثار التشوه الجنينى و السمية الجينية للمبيد الحشرى اللوفنيرون على الجرذان البيضاء الحوامل وأجنتها
260			_aCairo : _bAya Abdelnasser Mahmoud , _c2020
300			_a109 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Science - Department of Zoology
520			_aInsecticides and other agrochemicals have become indispensable components of the agricultural system to ensure a notable increase in crop yield and food production. As a natural consequence, chemical residues result in significantly increased contamination of both terrestrial and aquatic ecosystems.The present study evaluated the teratogenic, genotoxic, and oxidative stress effects of residual-level lufenuron exposure on pregnant rats during the organogenesis gestational period of both mother and fetus.The tested dams were divided into three groups; control (untreated), low-dose group (orally administered with 0.4 mg/kg lufenuron) and high-dose group (orally administered with 0.8 mg/kg lufenuron).The dams of the two treatment groups showed teratogenic abnormalities represented by the asymmetrical distribution of fetuses in both uterine horns, accompanied by observed resorption sites and intensive bleeding in the uterine horns, whereas their fetuses suffered from growth retardation, morphologic malformations, and skeletal deformations.Histologic examination of the liver and kidney tissues obtained from mothers and fetuses after lufenuron exposure revealed multiple histopathologic changes.DNA fragmentation and cell cycle perturbation were also detected in the liver cells of lufenuron-treated pregnant dams and their fetuses through comet assay and flow cytometry, respectively. Moreover, lufenuron-induced oxidative stress in the liver of mothers and fetuses was confirmed by the increased malondialdehyde (MDA) levels and decreased levels of enzymatic antioxidants (glutathione peroxidase [GPx] and superoxide dismutase [SOD]).Taken together, it can be concluded that lufenuron has a great potential in exerting teratogenic, genotoxic, and oxidative stresses on pregnant rats and their fetuses upon chronic exposure to residual levels during the organogenesis gestational period.The obtained results in the present study imply that women and their fetuses may have the same risk
530			_aIssued also as CD
653		4	_aHistopathology
653		4	_aLufenuron
653		4	_aTeratogenicity
700	0		_aAbdelrahman Tawfik , _eSupervisor
700	0		_aAmel Ramadan Omar , _eSupervisor
700	0		_aWesam Taha Basal , _eSupervisor
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c80371 _d80371