000			02833cam a2200325 a 4500
003			EG-GiCUC
008			210328s2019 ua d f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.11.08.Ph.D.2019.No.M
100	0		_aNoha Nabil Hayek
245	1	4	_aThe mini health technology assessment tool : _bAn application model on HCV and cancer patients / _cNoha Nabil Hayek ; Supervised Mona Ibrahim Ellawindi , Hanan Ali Sayed , Zeinab M. Abdelhafeez Elsayed
246	1	5	_aنموذج لتطبيق التقييم الصحى التكنولوجى على مرضى الفيروس الكبدى سى و الأورام
260			_aCairo : _bNoha Nabil Hayek , _c2019
300			_a141 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Community Medicine
520			_aBackground: HTA aims at helping decision makers in health care including hospitals make a scientific-based decision through efficient use of resources that considers all aspects a health technology affects namely 4 main parts: the clinical, the patient, the economic, and organization.Objectives: HTA was first designed to be used on a national level but with practice smaller scale versions were adapted to be used at hospital level, one of which is the mini-HTA. The study aimed to use mini-HTA to inform the decision for screening and consequent treatment of HCV positive cancer patients using direct acting antivirals which according to literature improves both hepatic and oncological outcomes, moreover it also decreases cost and DALYS.Results: The study showed that 8.8% of oncology patients were HCV positive during the study period. With the administration of chemotherapy liver functions decreased during that period as evident by increase in liver enzymes (AST- ALT) and decrease in albumin levels. Also, PCR levels increased in most patients (67.2%) indicating viral reactivation but wasn{u2019}t statistically correlated with the rise in liver enzymes indicating that they are an unreliable measure for viral reactivation.To measure quality of life EORTC-QLQ v30 core questionnaire was used.Comparing our results with the reference values revealed that the dual pathology reduced QOL scores of patients in physical function, role function and social function, all symptom scores, in addition to financial difficulties & global health score
530			_aIssued also as CD
653		4	_aDAA
653		4	_aHospital-based HTAA
653		4	_aHTA
700	0		_aHanan Ali Sayed , _eSupervisor
700	0		_aMona Ibrahim Ellawindi , _eSupervisor
700	0		_aZeinab M. Abdelhafeez Elsayed , _eSupervisor
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c80414 _d80414