000			03024cam a2200349 a 4500
003			EG-GiCUC
005			20250223032726.0
008			210410s2021 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.11.28.Ph.D.2021.He.A
100	0		_aHeba Ahmed Said Mahmoud Raslan
245	1	0	_aAssessment of serum activina level and its value as a biomarker for predicting subsequent asthma in wheezy infants / _cHeba Ahmed Said Mahmoud Raslan ; Supervised Mona Mustafa Elfalaki , Mohammed Abdelfattah Abdelmotey , Nihal Mohamed Elrifai
246	1	5	_aفى المصل كعلامة بيولوجية للتنبؤ بالربو اللاحق فى الرضع والأطفال الصغار المصابين بأزيز صدرى متكرر A تقييم مستوى أكتيفين
260			_aCairo : _bHeba Ahmed Said Mahmoud Raslan , _c2021
300			_a203 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Medicine- Department of Pediatrics
520			_aBackground: Activin A cytokine has grabbed attention regarding its role in inflammation and airway remodeling in asthma as it regulates airway inflammatory cells and airway remodeling. However, knowledge regarding its role in wheezy infants is limited. Patients and Methods: The present study was designed as a case control study that included two groups. First group, 40 Egyptian infants less than 2 years referred to the allergy clinic with history of their first or second attack of wheezing with mean age 14.925 ± 5.942 months with male to female ratio of 1.35, and second group, their matched control group (n=40). After comprehensive clinical assessment, blood samples were taken from the patients in order to assess serum activin-A, IgE and CBC measurements. Results: Patients had statistically significant higher activin A level compared to healthy controls (529.8 ± 358.4 vs 227.9 ± 63.4 pg/ml, p<0.001). Activin-A levels had a strong positive correlation with IgE levels (r=0.760) (p<0.001) and eosinophilic count (r=0.758) (p<0.001). Predictive ability of activin-A in discriminating wheezy infants from healthy controls showed that activin-A had high specificity of 95% and low sensitivity (55%). Mean serum activin A was significantly higher in patients who had history of recurrence of wheeze and hospital admission at follow-up. There were significant direct correlations between serum activin A and recurrence of wheezes, number of attacks and hospital admission within 6 months of the study at follow-up
530			_aIssued also as CD
653		4	_aActivin A
653		4	_aAsthma
653		4	_aChildren
700	0		_aMohammed Abdelfattah Abdelmotey , _eSupervisor
700	0		_aMona Mustafa Elfalaki , _eSupervisor
700	0		_aNihal Mohamed Elrifai , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c80577 _d80577