| 000 | 02542cam a2200325 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 008 | 210412s2021 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
||
| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.08.08.Ph.D.2021.Sh.P | ||
| 100 | 0 | _aShaymaa Elsayed Khater Elsayed | |
| 245 | 1 | 0 |
_aPharmaceutical study on fluoxetine hydrochloride nanocarriers / _cShaymaa Elsayed Khater Elsayed ; Supervised Dalia Mahmoud Mohamed Ghorab , Abdulaziz Mohsen Almahallawi , Hend Mohamed Abdelbar |
| 246 | 1 | 5 | _aدراسة صيدلية على حاملات نانومتريه للفلوكستين هيدروكلوريد |
| 260 |
_aCairo : _bShaymaa Elsayed Khater Elsayed , _c2021 |
||
| 300 |
_a160 P. : _bcharts , facsimiles ; _c25cm |
||
| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics | ||
| 520 | _aFirstly, the study investigates the feasibility of hexosomes (HEX) as a competent platform for fluoxetine hydrochloride (FH) repurposing against HepG2 hepatocellular carcinoma. Different FH-loaded HEX formulations were prepared and optimized by the hot emulsification method. The HEX features as particle size, zeta potential, and drug entrapment efficiency (EE %) can be tailored by tuning HEX components and fabrication conditions. The composition of the optimized FH hexosomes (OFH-HEX) was 3.1, 1.4, 0.5, 0.2, and 94.8% for glyceryl monooleate, oleic acid, pluronic F127, FH, and deionized water respectively. The anionic OFH-HEXwith a particle size of 145.5±2.5 nm and drug EE % of 45.4±1.2% was able to prolong in vitro FH release where only 19.5±2.3% released in PBS pH7.4 after 24 h. Contrarily, HEX rapidly released FH in acetate buffer pH5.5 and achieved a 90.5±4.7% release after 24 h which facilitates the passive targeting of FH to the cancer cells. Moreover, the obtained HEX showed an improved cellular internalization in a time-dependent manner and enhanced cytotoxicity (2-fold higher than FH solution). Consequently, this chapter suggests the potential of FH-HEX as a possible anticancer agent against hepatocellular carcinoma | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aFluoxetine hydrochloride | |
| 653 | 4 | _aHexosomes | |
| 653 | 4 | _aRepurposing | |
| 700 | 0 |
_aAbdulaziz Mohsen Almahallawi , _eSupervisor |
|
| 700 | 0 |
_aDalia Mahmoud Mohamed Ghorab , _eSupervisor |
|
| 700 | 0 |
_aHend Mohamed Abdelbar , _eSupervisor |
|
| 905 |
_aNazla _eRevisor |
||
| 905 |
_aShimaa _eCataloger |
||
| 942 |
_2ddc _cTH |
||
| 999 |
_c80627 _d80627 |
||