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003 EG-GiCUC
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008 210414s2020 ua d f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aPh.D
099 _aCai01.08.01.Ph.D.2020.Ma.P
100 0 _aMai Nabil Mohamed
245 1 0 _aPolymorphism in genes involved in blood coagulation system and its association with coronary artery diseases /
_cMai Nabil Mohamed ; Supervised Amal Ahmed Abdelfattah , Nermin Abdelhamid Sadik , Ahmed Abdelrahman Battah
246 1 5 _aالتحور فى الجينات المشاركة فى نظام تخثر الدم ومدى ارتباطه بأمراض الشريان التاجى
260 _aCairo :
_bMai Nabil Mohamed ,
_c2020
300 _a96 P . :
_bcharts ;
_c25cm
502 _aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry
520 _aHemostatic genes polymorphisms are well known to be associated with venous thrombosis, but their association with arterial thrombosis especially myocardial infarction (MI) remains to be clarified. The current study investigated the role of three hemostatic genes polymorphisms, prothrombin G20210A, factor XIII (FXIII) Val34Leu (G/T), and fibrinogen Ý- 455G/A and their coexistence in Egyptian patients with MI. The possible correlation of these polymorphisms with plasma fibrinogen level was also evaluated. The study included 120 patients with MI and 60 healthy volunteers. Gene polymorphisms were tested using multiplex polymerase chain reaction and reverse hybridization technique. Plasma fibrinogen level was determined by ELISA. The present study showed an increased risk of MI with fibrinogen Ý- 455G/A heterozygosity as well as FXIII Val34Leu homo and heterozygosity. In addition, the FXIII T allele (Leu34) and fibrinogen Ý-455A allele were significantly associated with MI. Conversely, the prevalence of prothrombin mutation did not differ between patients with MI and controls. Combined carriers of FXIII Leu34 and fibrinogen Ý-455A alleles were at higher risk of MI, whereas combined FXIII Val34Leu and prothrombin G20210A polymorphisms did not show increased risk for MI compared with controls. Plasma fibrinogen levels were significantly higher in patients with MI than controls. In MI patients, plasma fibrinogen levels were significantly higher in those with FXIII GT/TT or fibrinogen Ý-455G/A, while were significantly lower in those with prothrombin G20210A compared with patients with wild type genotypes
530 _aIssued also as CD
653 4 _aFXIII
653 4 _aMyocardial infarction
653 4 _aProthrombin
700 0 _aAhmed Abdelrahman Battah ,
_eSupervisor
700 0 _aAmal Ahmed Abdelfattah ,
_eSupervisor
700 0 _aNermin Abdelhamid Sadik ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aAmira
_eCataloger
905 _aNazla
_eRevisor
942 _2ddc
_cTH
999 _c80642
_d80642