000			02886cam a2200349 a 4500
003			EG-GiCUC
005			20250223032730.0
008			210419s2021 ua d f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.12.10.Ph.D.2021.Ha.S
100	0		_aHadeer Mohamed Diab Elhosseny
245	1	0	_aSynthesis of some novel bis- and multi-armed heterocycles / _cHadeer Mohamed Diab Elhosseny ; Supervised Ahmed Helmy Mahmoud Elwahy , Ismail Abdelshafy Abdelhamid , Moustafa Elsayed Ahmed
246	1	5	_aتشييد بعض الحلقات غير المتجانسة الثنائية و عديدة الأزرع المتماثلة الجديده
260			_aCairo : _bHadeer Mohamed Diab Elhosseny , _c2021
300			_a153 P. : _bcharts ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Science - Department of Organic Chemistry
520			_aPart 1: A synthesis of novel star-shaped compounds based on s-triazine core and linked to hexahydroacridinediones, pyrimido[4,5-b]quinolones, 1H-isoquinolino[2,1-a] quinolines, tetrahydro-4H-chromenes, dihydropyrano[2,3-c]pyrazoles, thiazole, or benzothiazole as new hybrid molecules through Michael and Hantzsch reactions is reported. For this purpose, the 2,4,6-tris(4-formylphenoxy)benzaldehyde was used as a versatile precursor. diones),-4,6-quinoline] b-(tetrahydropyrimido[4,5bis(sulfanediyl)bisnovel A synthesis of Part 2:5, as novel hybrid molecules -moieties at position oxindole-spirocycliclinked to aryl, heteroaryl, and was utilized as one)-)H4(1-aminopyrimidin-(6bis(sulfanediyl))bis diyl-1,4-(Butane-2,2'was reported. a precursor to our target compounds via a multicomponent reaction with two equivalents of both of the appropriate aldehyde and dimedone. The target compounds were alternatively obtained by bis-(alkylation) of the appropriate 5-aryl-2-thioxohexahydropyrimido [4,5-b]quinoline-4,6-dione with 1,4-dibromobutane in moderate basic medium. :Part 3 A novel series of bis(sulfanediyl)bis(tetrahydropyrimido[4,5-b]quinoline-4,6-diones) which are linked to benzene, pyridine, or thieno[4,5-d]thiophene cores was prepared utilizing bis(sulfanediyl))bis(6-aminopyrimidin-4(1H)-ones) as precursors. The target molecules were alternatively prepared via the bis-alkylation reactions of the appropriate 5-aryl-2-thioxohexahydro pyrimido[4,5-b] quinoline-4,6-dione with the corresponding dibromo compounds
530			_aIssued also as CD
653		4	_aHeterocycles
653		4	_aMulti-armed
653		4	_aNovel bis
700	0		_aAhmed Helmy Mahmoud Elwahy , _eSupervisor
700	0		_aIsmail Abdelshafy Abdelhamid , _eSupervisor
700	0		_aMostafa Elsayed Ahmed , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c80704 _d80704