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| 005 | 20250223032730.0 | ||
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_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.12.04.Ph.D.2021.Ma.N | ||
| 100 | 0 | _aMarwa Mohamed Mohamed Ahmed Sharaky | |
| 245 | 1 | 0 |
_aNovel diaryl urea based compounds : _bMechanistic study and anticancer biological evaluation / _cMarwa Mohamed Mohamed Ahmed Sharaky ; Supervised Monira Mohamed Rageh , Samia Abdelsamieh Shouman , Khaled Abouzid Mohamed |
| 246 | 1 | 5 |
_aدراسه اليه و تقييم بيولوجى كمضادات للسرطان : _bمركبات ثنائى مشتقات الفنيل يوريا |
| 260 |
_aCairo : _bMarwa Mohamed Mohamed Ahmed Sharaky , _c2021 |
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| 300 |
_a2016 P . : _bcharts,facsmilies ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biophysics | ||
| 520 | _aBreast cancer is the most common cancer diagnosed in women. Tamoxifen (TAM) is the gold standard in therapy of estrogen receptor positive breast cancer (ER+ BC), however its efficacy is challenged by acquired resistance. Angiogenesis plays fundamental roles in TAM resistance where VEGFR-2 is a key player in this process. Thus, targeting of VEGFR-2 signaling pathway has been an attractive approach for BC therapy. In this study, we synthesized a new thieno[2,3-d]pyrimidine based urea derivative KM6, which exhibited potential antitumor activity in both TAM-sensitive MCF7 and TAM-resistant LCC2 BC cells. In addition to its antiangiogenic properties, KM6 retained the sensitivity of LCC2 via modulation of key proteins and enzymes of apoptosis and cell death (caspases 3,8,9, survivin, P53, BAX, BCL-2, LDH) and ROS. Moreover, KM6 modulated vital biological markers of inflammation (PGE2, COX2, IL-1Ý and IL6) and metastasis (MMP-2 and MMP-9). Thus, KM6 is a promising compound for ER+ and TAM-resistant BC with polypharmacological properties | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aBreast cancer | |
| 653 | 4 | _aThieno[2,3-d]pyrimidine | |
| 653 | 4 | _aVEGFR-2 | |
| 700 | 0 |
_aKhaled Abouzid Mohamed , _eSupervisor |
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| 700 | 0 |
_aMonira Mohamed Rageh , _eSupervisor |
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| 700 | 0 |
_aSamia Abdelsamieh Shouman , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
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_aAmira _eCataloger |
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| 905 |
_aNazla _eRevisor |
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_2ddc _cTH |
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_c80724 _d80724 |
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