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| 003 | EG-GiCUC | ||
| 005 | 20250223032730.0 | ||
| 008 | 210424s2021 ua d f m 000 0 eng d | ||
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_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.08.05.Ph.D.2021.Na.A | ||
| 100 | 0 | _aNabila Abdalkareem Ali Alshoba | |
| 245 | 1 | 0 |
_aAnalytical studies of some drugs affecting central nervous system / _cNabila Abdalkareem Ali Alshoba ; Supervised Ehab Farouk Elkady , Marwa Ahmed Fouad |
| 246 | 1 | 5 | _aدراسات تحليلية على بعض الأدوية المؤثرة على الجهاز العصبي المركزي |
| 260 |
_aCairo : _bNabila Abdalkareem Ali Alshoba , _c2021 |
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| 300 |
_a179 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry | ||
| 520 | _aDifferent methods for the determination of certain drugs in laboratory mixtures and in pharmaceutical dosage formsor in biological fluids have been applied in this thesis. These drugs are Aripiprazole, Clomipramine, Clonazepam, desvenlafaxine, Escitalopram, L-methylfolate, Nortriptyline, pregabalin, Sertraline, venlafaxine and vilazodone. Chromatographic part includes the use of High Performance Liquid Chromatographic Method with Tandem Mass Detection for simultaneous determination of Aripiprazole, Clomipramine,Sertraline and vilazodone(Application to an in vivo pharmacokinetic study of drug-herb metabolic interaction potential of Khat).RP- HPLC for simultaneous determination of two binary mixtures, L-methylfolate (L-MF) and Clonazepam (CLO) with Escitalopram oxalate (ESC) in laboratory prepared mixtures and in pharmaceutical dosage forms.RP-HPLC-UV Detection Method for the Simultaneous Determination of Venlafaxine and its major active metabolite Desvenlafaxine in laboratory mixture and dosage form. RP-HPLC-UV Detection Method for the Simultaneous Determination of Pregabalin and Nortriptyline in laboratory mixture and dosage form. Spectroscopic part includes the use of PLS technique for the simultaneous determination of Escitalopram and Clonazepam and simultaneous determination of Venlafaxine and Desvenlafaxine. Statistical comparison between the results obtained by the proposed methods and reference methods were carried out | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aAripiprazole | |
| 653 | 4 | _aClomipramine | |
| 653 | 4 | _aClonazepam | |
| 700 | 0 |
_aEhab Farouk Elkady , _eSupervisor |
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| 700 | 0 |
_aMarwa Ahmed Fouad , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
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| 905 |
_aShimaa _eCataloger |
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_2ddc _cTH |
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_c80730 _d80730 |
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