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040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aM.Sc
099 _aCai01.24.05.M.Sc.2019.Ji.P
100 0 _aJilan Saber Rizk Ibrahim
245 1 0 _aPolypyrrole-Gold nanocomposites as a photothermal agent for murine cancer treatment /
_cJilan Saber Rizk Ibrahim ; Supervised Tarek Abdallah Etayeb , Neamat Hanafi Ahmed , Mahmoud Ashour Sliem
246 1 5 _aمتراكبات النانو من البوليبيرول- الذهب كعامل ضوئى حرارى لعلاج سرطان الفئران
260 _aCairo :
_bJilan Saber Rizk Ibrahim ,
_c2019
300 _a101 P. :
_bcharts ;
_c25cm
502 _aThesis (M.Sc.) - Cairo University - National Institute of Laser Enhanced Sciences (NILES) - Department of Laser Application Environmental Metrology, Photochemistry photobiology and Agriculture
520 _aPhotothermal nanoplatforms with good biocompatibility are greatly desired in the exploration of novel therapeutic methodologies. The surface coating of gold nanorods (Au NRs) by polypyrrole nanoparticles (PPy NPs) can be used not only in increasing the biocompatibility of Au NRs for treatment, but also in enhancing their photothermal efficiency. Polypyrrole-gold nanocomposites (PPy-Au NCs) were synthesized using ex-situ polymerization method of the modified pyrrole monomer. This work demonstrated the synthesis of PPy-Au NCs and their photothermal effect, in comparison to Au NRs and PPy NPs. Additionally, histological analysis was performed to investigate the efficiency of PPy-Au NCs in reducing tumor progression and ablating Ehrlich carcinoma (EC) bearing mice using polychromatic, polarized and low energy (PPLE) light source. PPLE light sources could provide a safer and more practical approach to photothermal therapy (PTT).Therefore, we propose that PTT based on PPy-Au NCs as a photothermal agent and the polychromatic, polarized and low energy light as a power source can serve as a new effective treatment for cancer tumors. This work will be useful for designing enhanced photothermal properties and further applications in nanomedicine
530 _aIssued also as CD
653 4 _aMurine cancer treatment
653 4 _aPhotothermal agent
653 4 _aPolypyrrole-Gold nanocomposites
700 0 _aMahmoud Ashour Sliem ,
_eSupervisor
700 0 _aNeamat Hanafi Ahmed ,
_eSupervisor
700 0 _aTarek Abdallah Etayeb ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aShimaa
_eCataloger
942 _2ddc
_cTH
999 _c80912
_d80912