000			03069cam a2200325 a 4500
003			EG-GiCUC
008			210529s2021 ua d f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.18.M.Sc.2021.Am.P
100	0		_aAmr Mohammed Abdelfattah
245	1	0	_aPrevalence of anti-erythropoietin receptor auto-antibodies in Egyptian patients on regular haemodialysis receiving erythropoietin{u2013}stimulating agents / _cAmr Mohammed Abdelfattah ; Supervised Hala Mahmoud Abdelhamid , Reham Abdelghany Ahmed , Eman Alhussain Abdulgawad
246	1	5	_aمعدل انتشار الأجسام المضادة الذاتية لمستقبلات الإريثروبيوتين فى المرضى المصريين الذين يخضعون للغسيل الكلوى الدموى المنتظم و يتناولون عوامل تحفيز الإريثروبيوتين
260			_aCairo : _bAmr Mohammed Abdelfattah , _c2021
300			_a73 P. : _bcharts ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Internal Medicine
520			_aRationale: Anemia is a major complication of chronic kidney disease associated with poor quality of life with increased morbidity and mortality. Additionally, it accelerates the rate of progression of chronic kidney disease. Erythropoietin stimulating agents are used to treat anaemia associated with chronic kidney disease; however some patients don{u2019}t achieve the desired haemoglobin concentration despite higher doses of erythropoietin stimulating agent.Several studies increase awareness of ESA hypo responsiveness, correlate hypo responsiveness to the presence of anti-EPO receptor antibodies and correlate their presence to the severity of anaemia Purpose: This study aims to evaluate the presence of anti EPO receptor antibodies on regular haemodialysis patients on ESA and assess the relationship between their presence and ESA hypo responsiveness Methodology : The present study included 77 patients on regular hemodialysis receiving Erythropoietin stimulating therapy. Patients were recruited from dialysis unit at KasrEl Einy hospital over the period from December 2019 to October 2020.The patients were investigated for CBC, renal function tests, iron profile, PTH and anti EPO receptor antibodies. Results:The study shows that 30% of included cases have anti-ESAR ab, we found no statistically significant relation with demo graphic, clinical and laboratory data except for parathyroid hormone, additionally we found no relation between antibodies and degree of Anaemiaor erythropoietin resistive index
530			_aIssued also as CD
653		4	_aAnti-erythropoietin receptor
653		4	_aAuto-antibodies
653		4	_aHaemodialysis
700	0		_aEman Alhussain Abdulgawad , _eSupervisor
700	0		_aHala Mahmoud Abdelhamid , _eSupervisor
700	0		_aReham Abdelghany Ahmed , _eSupervisor
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c81071 _d81071