000			02645cam a2200325 a 4500
003			EG-GiCUC
008			210619s2020 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.12.05.Ph.D.2020.Ra.D
100	0		_aRania Ahmed Talaat Abdelzaher
245	1	0	_aDickkopf-1 (DKK1), Midkine (MDK), and Golgi-protein 73 (GP73) as predictor markers of Hepatocellular carcinoma in comparison with Ü-Fetoprotein (AFP) in chronic Hepatitis C virus patients / _cRania Ahmed Talaat Abdelzaher ; Supervised Elsayed Tarek Abdelsalam , Abdelrahman Nabwy Zekri , Mohamed Mahmoud Zakaria Elkassas
246	1	5	_aفى المرضى ذوى الاصابه المزمنه بفيروس ج (HCC)بالمقارنة ببروتين الفافيتوبروتين كدلالات للكشف المبكر عن الاورام السرطانيه الكبديه (GP73)وبروتين جولوجى ٧٣(MDK )ميديكين(DKK1)تقدير كل من البروتينات ديكوف- ١
260			_aCairo : _bRania Ahmed Talaat Abdelzaher , _c2020
300			_a152 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Science - Department of Botany and Microbiology
520			_aHepatocellular carcinoma (HCC) is the second most common cause of cancer related death worldwide. The use of alpha fetoprotein (AFP) alone was not an accurate biomarker for HCC despite its high specificity. In the current study we assessed the expression levels of Golgi protein 73 (GP73), Midkine (MDK) and Dickkopf-1(DKK-1) proteins separately and in combination at different stages of hepatocarcinogenesis. The ROC curve analysis for the studied markers showed (1) 88.5% sensitivity, 80.6% specificity, 69% PPV , 93.5% NPV and (AUC 0.91) for MDK; (2) 93.6%, 86.9%, 77.7%, 96.5% for DKK-1. (3) 91%, 85%, 74.7%, 95% (AUC 0.96) for GP73, and (4) 74.4%, 84.4%, 69.9%, 87.1% (AUC 0.81) for AFP. Serum levels of GP73, MDK, and DKK-1 are comparable to AFP as diagnostic biomarkers for early detection of HCC patients from Egypt. A two markers panel including Gp73 and DKK-1 showed the highest specificity and sensitivity among different markers combinations
530			_aIssued also as CD
653		4	_aGolgi-protein 73
653		4	_aHepatocellular carcinoma
653		4	_aMidkine, Dickkopf-1
700	0		_aAbdelrahman Nabwy Zekri , _eSupervisor
700	0		_aElsayed Tarek Abdelsalam , _eSupervisor
700	0		_aMohamed Mahmoud Zakaria Elkassas , _eSupervisor
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c81336 _d81336