000			03182cam a2200349 a 4500
003			EG-GiCUC
005			20250223032751.0
008			210622s2021 ua d f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.28.M.Sc.2021.Ma.E
100	0		_aMaryan Ibrahem Yousef
245	1	0	_aEffect of phototherapy on the expression of neutrophil surface markers in neonates with indirect hyperbilirubinemia / _cMaryan Ibrahem Yousef ; Supervised Walaa Alsharany Abuelhamd , Angie Mohamed Samir Tosson , Nouran Mohamed Nabil Momen
246	1	5	_aتأثير العلاج الضوئي على الدلالات السطحية لخلايا الدم البيضاء المتعادلة فى حديثى الولادة المصابين باليرقان الوليدى الغير مباشر
260			_aCairo : _bMaryan Ibrahem Yousef , _c2021
300			_a176 P . : _bcharts ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics
520			_aBackground :Indirect hyperbilirubinemia affects more than 60% of neonates and phototherapy is the standard method of treatment. Its effects on different blood cell counts and characteristics are still being studied. Objective: To evaluate the effect of phototherapy on neutrophil functions through assessing the expression of CD16, CD11c, and CD10, and other complete blood count (CBC) parameters. Patients and methods: This prospective cohort study included 54 newborns {u2265} 35 weeks of gestation and weighing {u2265}2.5 kg presenting with indirect neonatal hyperbilirubinemia which required only phototherapy. They were recruited from the neonatal intensive care unit(NICU) of Cairo University Children{u2019}s Hospital. Neutrophil surface markers and CBC parameters were measured before and after phototherapy. Results: There was an increase in CD16, CD10 expression after phototherapy by a mean change of 32.13±76.98% and 58.67±271.91% respectively, and a decrease in CD11c expression by a mean change of -0.7±53.95% with P-values of 0.002, 0.011, and 0.008 respectively. Statistically significant decreases in hemoglobin (Hb), red blood cell count (RBC), red cell distribution width (RDW), hematocrit concentration (Hct), mean corpuscular volume (MCV) and reticulocytic count were also detected (all Pvalues <0.001). The present study revealed no statistically significant differences in other white blood cell parameters apart from immature/total (I/T) ratio, neutrophils%, lymphocytes%, eosinophils% (P values <0.05). A decrease in platelet count and volume after phototherapy was also detected by a mean change of -2.14±23.67% and -7.91±10.25%, respectively
530			_aIssued also as CD
653		4	_aIndirect hyperbilirubinemia
653		4	_aNeonates
653		4	_aPhototherapy
700	0		_aAngie Mohamed Samir Tosson , _eSupervising
700	0		_aNouran Mohamed Nabil Momen , _eSupervising
700	0		_aWalaa Alsharany Abuelhamd , _eSupervising
856			_uhttp://172.23.153.220/th.pdf
905			_aAmira _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c81351 _d81351