000			02850cam a2200349 a 4500
003			EG-GiCUC
005			20250223032752.0
008			210624s2021 ua d f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.28.M.Sc.2021.Ma.O
100	0		_aMarwa Rabea Ahmed Hassan
245	1	0	_aOsteoprotegerin and Osteoprotegerin ligand serum levels and bone health in Ý -Thalassemia patients / _cMarwa Rabea Ahmed Hassan ; Supervised Ilham Youssry Mohamed Ibrahim , Rania Mohamed Samy , Dalia Salaheldin Ahmed
246	1	5	_aمستويات الاوستوبروتيجيرين و رابط الاوستوبروتيجيرين فى مصل الدم وصحه العظام فى مرضى الثلاسميا
260			_aCairo : _bMarwa Rabea Ahmed Hassan , _c2021
300			_a119 P . : _bcharts ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics
520			_aBackground: Osteoporosis is a notable cause of morbidity in thalassemia major (TM) patients with a complex pathophysiology and multifactorial etiology. Osteoprotegerin (OPG) and osteoprotegerin ligand (OPGL) have been recently implicated in the pathogenesis of osteoporosis. Aims: To measure the level of OPG and OPGL serum levels in patients with Ý thalassemia and to evaluate the relation between the OPG&OPGL level and the bone mineral density (BMD) in children with Thalassemia Major. Patients and methods: In 60 Egyptian thalassemic patients and 60 healthy control children (age = 5-14 year), serum OPG and serum OPGL measured by ELIZA. The patients had recent results of BMD scanning using dual X-ray absorptiometry (DEXA).Results: High prevalence of bone diseases was detected in TM patients, 40% had spine low bone mass, 10% had femur low bone mass, 70% complained from bone pain and 21.7% had history of fracture of long bone. The thalassemic patients showed significantly lower serum levels of OPG (P=0.003) and lower serum levels of OPGL (P=0.002) OPG/ OPGL ratio (P=0.019) as compared with controls. We couldn{u2019}t demonstrate significant association between serum OPG & serum OPGL levels and BMD.Conclusions: Our data underline the important role of the OPG {u2013} OPGL system in the pathogenesis of osteoporosis in thalassemia major, which could be a potential target for novel therapeutic agents
530			_aIssued also as CD
653		4	_aOsteoporosis
653		4	_aOsteoprotegerin (OPG)
653		4	_aThalassemia major (TM)
700	0		_aDalia Salaheldin Ahmed , _eSupervising
700	0		_aIlham Youssry Mohamed Ibrahim , _eSupervising
700	0		_aRania Mohamed Samy , _eSupervising
856			_uhttp://172.23.153.220/th.pdf
905			_aAmira _eCataloger
905			_aNazla _eRevisor
942			_2ddc _cTH
999			_c81382 _d81382