000			03309cam a2200337 a 4500
003			EG-GiCUC
005			20250223032753.0
008			210627s2020 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.09.14.Ph.D.2020.Se.I
100	0		_aSeham Hazem Mohammed Elayouti
245	1	0	_aImmunohistochemical expression of fak and pcna in odontogenic keratocyst, orthokeratinized odontogenic cyst, dentigerous cyst and glandular odontogenic cyst : _bIn vitro study / _cSeham Hazem Mohammed Elayouti ; Supervised Heba Mahmoud Dahmoush , Hatem Wael Amer
246	1	5	_aفى الكيس الكرايتينى السنى وكيس الكيراتين المصطف والكيس المسنن والكيس الغدى السنى PCN و FAC التعبير المناعى الهيستوكيميائى : _bدراسه فى المختبر
260			_aCairo : _bSeham Hazem Mohammed Elayouti , _c2020
300			_a94 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Oral and Maxillofacial Pathology
520			_aBackground: Odontogenic cysts are distinctive disorders that affect oral and maxillofacial tissues. The majority of odontogenic cysts such as dentigerous cysts (DCs) and orthokeratinized odontogenic cyst (OOCs) show an indolent course, whilst others demonstrate an aggressive behavior and may have higher recurrence rate like odontogenic keratocysts (OKCs) and glandular odontogenic cysts (GOCs). Aim: This study aimed to compare FAK and PCNA expression in OKC, OOC, DC and GOC and to attempt to correlate the findings to their variable clinical behaviors. Moreover, this study aimed to clarify the role of EMT in invasion potential, proliferation and aggressiveness of these lesions, thus helping to predict their prognosis, reaching the best treatment modality for the patients and lowering the recurrence rates. Methodology: Double Immunostaining technique for FAK and PCNA was performed on the same tissue specimens using two types of chromogens (DAB and AEC). DAB chromogen was used for the assessment of nuclear expression of PCNA, while AEC chromogen was used for the assessment of cytoplasmic expression of FAK. Results: The greatest mean of the nuclear immunoexpression of PCNA was recorded in GOC group, followed by the OKC and OOC groups, whereas the lowest value was the DC group, while the greatest mean area percent of the cytoplasmic expression of FAK was recorded in OKC group, followed by the GOC and OOC groups, whereas the lowest value was recorded in DC group. Conclusions: OKC has the highest EMT ability followed by GOC, while GOC has the highest proliferation activity followed by OKC. On the other hand, OOC and DC have the lowest EMT ability and proliferation activity, which can explain the diverse behavior of those odontogenic cysts
530			_aIssued also as CD
653		4	_aOdontogenic cysts
653		4	_aOdontogenic keratocysts (OKCs)
653		4	_aPCNA
700	0		_aHatem Wael Amer , _eSupervisor
700	0		_aHeba Mahmoud Dahmoush , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c81406 _d81406