000			03098cam a2200349 a 4500
003			EG-GiCUC
005			20250223032755.0
008			210706s2021 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.11.10.Ph.D.2021.Ah.A
100	0		_aAhmed Hesham Ezz Eldin Mohamed Mourad
245	1	0	_aAssessment of PD-1 and PD-L1 levels in vitiligo patients : _bCase control study / _cAhmed Hesham Ezz Eldin Mohamed Mourad ; Supervised Hanan Rabea Nada , Ghada Mohamad Elhanafi , Mohamed Abdelhady
246	1	5	_aفي مرضى البهاق PD-L1 1-ولجين موت الخلية المبرمج PD-1 1- تقييم مستوى عامل موت الخلية المبرمج : _bدراسة الحالات والشواهد
260			_aCairo : _bAhmed Hesham Ezz Eldin Mohamed Mourad , _c2021
300			_a109 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology
520			_aBackground: Programmed cell death 1 (PD-1) is an immune checkpoint cell surface protein with two ligands, PD-L1 and PD-L2. PD-1/PD-L1 interactions are essential for peripheral T cell tolerance and protecting tissues from autoimmune attack. PD- 1/PD-L1 checkpoint is implicated in multiple autoimmune diseases, and recently were suggested to have a role in vitiligo development due to the high incidence of vitiligo like lesions as an adverse effect of PD-1/PD-L1 blockade. Aim of work: To assess both PD-1 and PD-L1 levels in vitiligo patients{u2019} marginal and nonlesional biopsies in comparison with normal controls, and to correlate them with disease parameters. Methods: 30 vitiliginous patients and 30 age and sex matched controls were included. Full history and clinical examination were done and tissue levels of PD1 were measured by ELISA from lesional and nonlesional biopsies. Results: Levels of tissue PD-1 in marginal biopsies were significantly higher than in nonlesional biopsies (p<{u2009}.001) and significantly higher than control PD-l level (p<{u2009}.001). Nonlesional PD-1 level was also significantly higher than control PD-l level (p<{u2009}.001). A statistically significant positive correlation was found between marginal and nonlesional PD-1 levels; (rho=0.792, p<{u2009}.001). Levels of tissue PD-L1 in marginal biopsies were significantly lower than in nonlesional skin (p<0.001) and significantly lower than in controls (P<0.001). Nonlesional PD-L1 level was also significantly lower than control PD-Ll level (p<{u2009}.001). Conclusion: PD-1/PD-L1 may be involved in the pathogenesis of vitiligo
530			_aIssued also as CD
653		4	_aProgrammed cell death 1
653		4	_aTolerance
653		4	_aVitiligo
700	0		_aGhada Mohamad Elhanafi , _eSupervisor
700	0		_aHanan Rabea Nada , _eSupervisor
700	0		_aMohamed Abdelhady , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c81486 _d81486