000			03135cam a2200349 a 4500
003			EG-GiCUC
005			20250223032814.0
008			210913s2021 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.10.M.Sc.2021.Ma.A
100	0		_aMai Ramzi Helmi Alfarra
245	1	0	_aAssessment of ENHO gene polymorphism in psoriasis vulgaris and its relation to Metabolic Syndrome parameters / _cMai Ramzi Helmi Alfarra ; Supervised Dina Mohammed Kadry Ismail , Mona Mohamed Ibrahim Elkalioby , Olfat Gamil Shaker
246	1	5	_aلدى مريض الصدفية وتحديد علاقته بمتلازمة التمثيل الغذائى ENHO تقييم تعدد الشكل الجنينى
260			_aCairo : _bMai Ramzi Helmi Alfarra , _c2021
300			_a182 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Dermatology
520			_aObjective: Evaluation of ENHO gene polymorphism (rs2281997, rs72735260) and serum adropin levels in patients with psoriasis and determining their relation to metabolic syndrome. Patients And Methods: The study included 150 patients with psoriasis vulgaris and 150 matched controls. Each group was further divided according to presence/absence of metabolic syndrome into two subgroups. Detailed history, body surface area (BSA), PASI score, dermatology life quality index (DLQI) were recorded for all patients. Metabolic parameters were tested for both patients and controls. ENHO gene polymorphism (rs2281997 and rs72735260) were detected by Taqman technique for all patients and controls. Adropin level was assessed for 40 psoriasis patients and 40 controls using ELISA.Results: TT genotype and T allele variant of rs2281997 (C/T) gene were associated with psoriasis (p<0.001* and p=0.004* respectively) .TT genotype and T allele variant of rs2281997 (C/T) gene were also associated with increased systolic (p= 0.011* and 0.001* respectively) and diastolic blood pressure (p= 0.018* and 0.004* respectively). C allele of rs2281997 was statistically more frequently associated with scalp type of psoriasis (P=0.006*).There was no difference in the prevalence of rs72735260 (G/T) genotypes (p=0.493) and allele variants (p =0.522) between psoriasis patients and controls. However, GT genotype of rs72735260 (G/T) gene was associated with elevated serum cholesterol (p= 0.046*). GT genotype and T allele of rs72735260 (G/T) gene were associated with earlier age of onset of psoriasis (p= 0.023* and p=0.035* respectively) and with the type I psoriasis (P =0.028* and 0.018* respectively)
530			_aIssued also as CD
653		4	_aMetabolic Syndrome parameters
653		4	_aPolymorphism
653		4	_aPsoriasis vulgaris
700	0		_aDina Mohammed Kadry Ismail , _eSupervisor
700	0		_aMona Mohamed Ibrahim Elkalioby , _eSupervisor
700	0		_aOlfat Gamil Shaker , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c82101 _d82101