000 03674cam a2200349 a 4500
003 EG-GiCUC
005 20250223032814.0
008 210913s2020 ua dh f m 000 0 eng d
040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aM.Sc
099 _aCai01.11.07.M.Sc.2020.Sa.S
100 0 _aSandra Tharwat Kamel Karas
245 1 0 _aSerum 25-hydroxyvitamin D Level relationship with potential cardiomyopathic changes in nutritional rickets /
_cSandra Tharwat Kamel Karas ; Supervised Iman Atef Mandour , Doaa Mohamed Abdou Mostafa , Antoine Fakhry Abdelmassih
246 1 5 _aالعلاقة بين مستوى " 25 هيدروكسى فيتامين د" فى الدم وتغيرات الضعف المحتملة فى عضلة القلب فى مرضى الكساح التغذوى
260 _aCairo :
_bSandra Tharwat Kamel Karas ,
_c2020
300 _a119 P. :
_bcharts , facsimiles ;
_c25cm
502 _aThesis (M.Sc.) - Cairo University - Faculty of Medicine- Department of Clinical and Chemical Pathology
520 _aBackground: Rickets is a bone disease that is associated with decreased serum calcium and/or phosphate levels in the blood, leading primarily to widening and delay of mineralization of growth plates in bones. Nutritional rickets can be caused by deficiencies of vitamin D, calcium or phosphate attributable to nutritional or environmental causes. Cardiovascular involvement, namely cardiomyopathy, is an important complication in these patients. Early assessment of vitamin D status and heart functions allows the detection of subclinical myocardial involvement before proceeding to overt myocardial dysfunction. We aimed to study myocardial function in nutritional rickets patients using 3D Speckle Tracking Echocardiography and assessment of Brain Natriuretic Peptide level in patients{u2019} serum and correlating it to vitamin D status. Methodology: Thirty four patients with nutritional rickets, age ranged from 3 months to 12 years of both genders, were compared to thirty four healthy age and sex matched children. Cases and controls were subjected to clinical examination, laboratory assessment of vitamin D, BNP and routine investigations (total calcium, phosphorus, alkaline phosphatase, ionized calcium, sodium, potassium and albumin). 3D Speckle Tracking Echocardiography was also performed to children of both groups. Results: We found statistically significant differences between the two studied groups regarding vitamin D, total calcium and ionized calcium levels which were significantly lower in cases of nutritional rickets than control group (p-value was <0.001, 0.002 and <0.001 respectively). Alkaline phosphatase and BNP levels were significantly higher in cases of nutritional rickets than control group (p-value was <0.001 and 0.001 respectively).There was significant difference in 3D STE parameters between cases and controls. LV and RV GLS were significantly lower in cases of nutritional rickets than control group (p-value was <0.001 for both), denoting systolic dysfunction and LV and RV E/E{u2019} were significantly higher in cases of nutritional rickets than control group (p-value was <0.001 and 0.001 respectively), denoting diastolic dysfunction
530 _aIssued also as CD
653 4 _aCardiomyopathy
653 4 _aNutritional rickets
653 4 _aVitamin D
700 0 _aAntoine Fakhry AbdelMassih ,
_eSupervisor
700 0 _aDoaa Mohamed Abdou Mostafa ,
_eSupervisor
700 0 _aIman Atef Mandour ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aNazla
_eRevisor
905 _aShimaa
_eCataloger
942 _2ddc
_cTH
999 _c82102
_d82102