| 000 | 02541cam a2200349 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223032844.0 | ||
| 008 | 211107s2021 ua dh f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aPh.D | ||
| 099 | _aCai01.11.28.Ph.D.2021.Ma.A | ||
| 100 | 0 | _aMary Maher Zaher Botros | |
| 245 | 1 | 0 |
_aAssociation between C1q rs631090 gene polymorphism and juvenile systemic lupus erythematosus in Egyptian children: _bA single centre study / _cMary Maher Zaher Botros ; Supervised Samia Salah Eldin Mahmoud , Hala Mohamad Lotfy , Yomna Mohamed Farag |
| 246 | 1 | 5 |
_aو داء الذئبة الحمراء لدى الأطفال المصريين : C1q rs631090 العلاقة بين تعدد أشكال جين : _bدراسة مركز واحد |
| 260 |
_aCairo : _bMary Maher Zaher Botros , _c2021 |
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| 300 |
_a106 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pediatrics | ||
| 520 | _aSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease. It is characterized by multiple autoantibodies associated with a multisystem illness.C1q deficiency is related strongly to systemic lupus erythematosus (SLE).The aim of this study is to assess and characterize C1q rs 631090 polymorphism in a group of Egyptian children with jSLE and and to investigate the relationship between this polymorphism and phenotypes and damage index.The study included 67 patients diagnosed as having jSLE according to the Systemic Lupus International Collaborating Clinics(SLICC)(Petri et al.,2012) and ACR criteria following up at pediatric rheumatology department, Abu ElResh Hospital, Cairo University and 47controls recruited from outpatient clinic coming for routine investigations.Data was collected from each patient , blood sample collected from all enrolled subjects and the DNA was genotyped forc.187+267T>C(rs631090) showing 35.8% having gene mutation of which 13.4% homozygous mutation C/Cand 22.4% heterozygous mutation C/T while 64.2% patients were wild homozygous T/T | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aC1q deficiency | |
| 653 | 4 | _aDamage index | |
| 653 | 4 | _aJuvenile SLE | |
| 700 | 0 |
_aHala Mohamad Lotfy , _eSupervisor |
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| 700 | 0 |
_aSamia Salah Eldin Mahmoud , _eSupervisor |
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| 700 | 0 |
_aYomna Mohamed Farag , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
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| 905 |
_aShimaa _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c83040 _d83040 |
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