000			02923cam a2200325 a 4500
003			EG-GiCUC
008			211114s2021 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.12.21.M.Sc.2021.Mo.A
100	0		_aMona Yousry Mahmoud Osman
245	1	0	_aAssessment of immunological, parasitological and histopathological parameters after treatment with nitazoxanide and allium sativum (garlic) against murine cryptosporidiosis / _cMona Yousry Mahmoud Osman ; Supervised Alyaa Ahmed Farid , Wajet Nabil , Ibrahim Rabae Shalash
246	1	5	_aتقييم القياسات المناعية والطفيلية والنسيجية المرضية بعد العلاج بالنيتازوكسانيد والثوم ضد الكريبتوسبورديوزس فى الفئران
260			_aCairo : _bMona Yousry Mahmoud Osman , _c2021
300			_a70 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology
520			_aCryptosporidium is a genus of apicomplexan parasitic alveolates that can cause a respiratory and gastrointestinal illness (cryptosporidiosis) that primarily involves watery diarrhea (intestinal cryptosporidiosis) with or without a persistent cough (respiratory cryptosporidiosis) in both immunocompetent and immunodeficient humans.The majority of chemotherapeutic agents used to treat parasitic disease are ineffective against cryptosporidiosis. Many compounds have been tested for their anti-cryptosporidial activity, but there is no effective therapy for preventing or treating cryptosporidiosis, particularly in immunocompromised individuals. Allium sativum has been used in many cultures for thousands of years in both food and medicine. The present study aimed to evaluate the efficacy of Allium sativum in treatment of cryptosporidiosis especially in immunosuppressed mice. Animals were divided into 8 groups (7 for each): Group I: Immunocompetent control mice, group II: Immunosuppressed control mice, group III: Non-treated immunocompetent infected mice, group IV: Non-treated immunosuppressed infected mice, group V: Nitazoxanide treated immunocompetent infected mice, group VI: Nitazoxanide treated immunosuppressed infected mice, group VII: Allium sativum treated immunocompetent infected mice and group VIII: Allium sativum treated immunosuppressed infected mice. 0.25 mg/g/day dexamethasone was orally administrated for14consecutive days prior to infection with C. parvum oocysts.
530			_aIssued also as CD
653		4	_a IL-10
653		4	_aAllium sativum
653		4	_aCryptosporidium
700	0		_aAlyaa Ahmed Farid , _eSupervisor
700	0		_aIbrahim Rabae Shalash , _eSupervisor
700	0		_aWajet Nabil , _eSupervisor
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c83134 _d83134