000			02710cam a2200313 a 4500
003			EG-GiCUC
008			211124s2021 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.08.08.M.Sc.2021.Ya.P
100	0		_aYasmeen Nader Mohamed Ezzeldeen
245	1	0	_aPreparation and evaluation of nanovesicles containing an anti-cancer herbal drug / _cYasmeen Nader Mohamed Ezzeldeen ; Supervised Aliaa Nabil Ahmed Elmeshad , Shady Aly Swidan Elkhouriby
246	1	5	_aتحضير وتقييم الحويصلات النانوية المحتوية على دواء عشبى مضاد للسرطان
260			_aCairo : _bYasmeen Nader Mohamed Ezzeldeen , _c2021
300			_a102 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics
520			_aHonokiol (HK) is a bioactive natural compound with proven antineoplastic properties against melanoma. However, HK shows very low bioavailabilitywhen administered orally. Alternatively, topical administration may offer a promising route, but is still challenging owing to the presence of physiological barriers, which are: the stratum corneum, the anomalous tumor microenvironment (TME) and itsinterstitial matrix. Herein, our objective was to fabricate HK loaded transfersomes (HKT) to enhance the HK bioavailability and to overcome these barriers and to enhance the topical drug delivery for melanoma treatment. Transfersomes (TFs) were prepared using the modified scalable heating method without using any organic solvents. The influence of the three fabrication variables: the loading drug amount, the stirring speed, and the speed of homogenization on the transfersomal particle size (PS), polydispersity index (PDI), zeta potential (ZP) and HK entrapment efficiency (EE) were assessed. It was found that the speed of homogenization exhibited a significant effect on the PS, PDI, ZP, and HK EE; while the stirring speed revealed a significant effect on the PS; and the loading drug amount affected the PDI and the HK EE. Surface response optimization was applied for the three process factors in order to select the optimized formula that was successfully prepared showing a small mean PS, a highly negative surface charge , and a high EE .
530			_aIssued also as CD
653		4	_aAnti-cancer herbal drug
653		4	_aMicroenvironment (TME)
653		4	_aNanovesicles
700	0		_aAliaa Nabil Ahmed Elmeshad , _eSupervisor
700	0		_aShady Aly Swidan Elkhouriby , _eSupervisor
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c83274 _d83274