000			03267cam a2200325 a 4500
003			EG-GiCUC
008			211128s2021 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.11.28.M.Sc.2021.Ah.S
100	0		_aAhmed Mahmoud Ahmed Sayed
245	1	0	_aSerum erythropoietin level for detection of kidney and brain injuries in asphyxiated neonates in neonatal intensive care unit / _cAhmed Mahmoud Ahmed Sayed ; Supervised Dina Mohamed Akmal , Yosra Aboelnaga Fahmy , Nermine Magdi Riad
246	1	5	_aمستوى الايرثروبيوتين فى الدم فى المبتسرين فى رعايه حديثي الولاده للتنبؤ باصابه الكلى والمخ بعد تعرضهم لنقص الأكسجين فى الولادة
260			_aCairo : _bAhmed Mahmoud Ahmed Sayed , _c2021
300			_a109 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics
520			_aBackground: Perinatal hypoxic-ischemic encephalopathy (HIE) is the leading cause of brain injury in the newborn and can result in long-term devastating consequences. Acute kidney injury (AKI) occurs in (50-72%) among asphyxiated term infants. Erythropoietin (EPO) is a hormone secreted by the kidney that stimulates the bone marrow for RBCs formation. The erythropoietin-producing kidney cells are sensitive to low oxygen levels in the blood that passes through the kidney.The aim of our study is to evaluate brain injury in full-term neonates with perinatal asphyxia by detecting specific biomarkers in the blood during fist days of life (erythropoietin). And evaluate kidney injury related to perinatal asphyxia. Materials and methods: A cross-sectional study included 80 full-term neonates in their first 96 hours of life: 40 healthy neonates, 14 newborns with clinical signs of mild HIE, 15 newborns with moderate HIE, 11 newborns of severe HIE. To study serum erythropoietin level for detection of kidney and brain injuries in asphyxiated neonates.Results: In our study we found that serum erythropoietin level was significantly higher in patients{u2019} group than control group. Serum erythropoietin level was significantly higher in severe cases of HIE than mild and moderate cases. In our study we found high serum creatinine level in patients group compared to controls group and this may reflect effect of hypoxia on kidney function. 50% of asphyxiated neonates were found to have AKI, and 95% were non-oliguric. In our study we found there was no significant difference between AKI group compared to non-AKI group as regard serum erythropoietin level. ROC curves were plotted for erythropoietin. Erythropoietin level greater than 10.5 mIU\ml showed a sensitivity of 67.5% and specificity of 82.5% and area under curve (AUC) of 70.0%
530			_aIssued also as CD
653		4	_aAcute Kidney Injury
653		4	_aFull-Term Neonates
653		4	_aHIE
700	0		_aDina Mohamed Akmal , _eSupervisor
700	0		_aNermine Magdi Riad , _eSupervisor
700	0		_aYosra Aboelnaga Fahmy , _eSupervisor
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c83328 _d83328