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008			211129s2021 ua dh f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aPh.D
099			_aCai01.11.13.Ph.D.2021.As.E
100	0		_aAsmaa Mohamed Abdelfattah Hussein
245	1	0	_aEvaluation of oxidative stress status and kidney affection among workers exposed to silica in an iron/steel foundry / _cAsmaa Mohamed Abdelfattah Hussein ; Supervised Dalia Ismail Attia , Laila Ahmed Rashed , Ghada Hossam Eldin Elsherief
246	1	5	_aتقييم حالة الإجهاد التأكسدى وتأثر الكلى بين العمال المعرضين للسيليكا فى مسبك للحديد
260			_aCairo : _bAsmaa Mohamed Abdelfattah Hussein , _c2021
300			_a154 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Forensic Medicine Clinical Toxicology
520			_aIntroduction: Despite of the fact that silica is encountered in numerous industries, silica exerts various adverse health effects among exposed workers, mainly on the respiratory and renal systems, through oxidative stress. Aim: The aim of this work was to study the changes of some oxidative stress indicators and renal alteration which may result from silica exposure among iron foundry workers. Subjects and methods: This study was conducted on 70 silica-exposed workers compared to 40 non-exposed individuals as a control group. The exposed group was further subdivided, according to chest X-ray (CXR) interpretation, into a silicotic subgroup (n=13) and a non-silicotic subgroup (n=57). The whole studied population was subjected to: full medical and occupational history, clinical examination, laboratory investigations including serum malondialdehyde (MDA), serum glutathione peroxidase (GPx), serum 8-hydroxydeoxyguanosine (8-HdG), serum creatinine, serum cystatin C, serum urea, urinary silica, urinary albumin and urinary Ü1-microglobulin. Also, all participants performed ventilatory function tests and the exposed group was subjected to radiological evaluation using plain CXR. Results: Statistically significant (p<0.001) higher values of urinary silica, urinary albumin, urinary Ü1-microglobulin, serum MDA, serum 8-HdG, serum creatinine, serum cystatin C and albumin creatinine ratio were detected among the exposed group compared to the controls. Statistically significant lower values of the estimated glomerular filtration rate (e-GFR), serum GPx, SVC%, FVC %, FEV1 % and FEV1/FVC % were detected in the exposed group compared to the controls (p<0.05). All the studied parameters showed statistically significant correlations with the urinary silica level
530			_aIssued also as CD
653		4	_aFoundry
653		4	_aOxidative stress
653		4	_aSilica
700	0		_aDalia Ismail Attia , _eSupervisor
700	0		_aGhada Hossam Eldin Elsherief , _eSupervisor
700	0		_aLaila Ahmed Rashed , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aNazla _eRevisor
905			_aShimaa _eCataloger
942			_2ddc _cTH
999			_c83350 _d83350