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040 _aEG-GiCUC
_beng
_cEG-GiCUC
041 0 _aeng
049 _aDeposite
097 _aPh.D
099 _aCai01.11.07.Ph.D.2021.Am.I
100 0 _aAmany Mahmoud Ahmed Mohamed
245 1 0 _aIn vitro antimicrobial activity of ceftazidime- avibactam tested against carbapenem resistant enterobacteriaceae and pseudomonas aeruginosa clinical isolates /
_cAmany Mahmoud Ahmed Mohamed ; Supervised Mona Mohieeden Abdelhaleem , Amal Mohamed Sayed , Doaa Mohammad Ghaith
246 1 5 _aاختبار النشاط المضاد للميكروبات لعقار سيفتازديم افيبكتام داخل المعمل ضد البكتيريا المعوية المقاومة للكاربابينيم وسودوموناس اريوجونوزا للعزلات المرضية
260 _aCairo :
_bAmany Mahmoud Ahmed Mohamed ,
_c2021
300 _a129 P . :
_bcharts , facsimiles ;
_c25cm
502 _aThesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology
520 _aBackgroung: The global spread of Carbapenem resistance organisms (CRO) has become a major public health concern especially regarding limited treatment options. Ceftazidime-avibactam (CZA) is a promising therapy for CRO causing infections Aim of work: we aimed to determine the prevalence of carbapenem resistant Enterobacteriaceae and Pseudomonas aeruginosa among clinical isolates and to investigate the in vitro antimicrobial susceptibility of CZA. Methods: Our study was conducted at Cairo university specialized pediatric hospital over one year. A total of 320 isolates were included. CZA.susceptibility testing was done disk diffusion method.The presence of carbapenemases was detected in 170 isolates by modified carbapenem inactivation method (mCIM) and multiplex PCR tests. Results: Prevalence of the prevalence of carbapenem resistant Enterobacteriaceae and Pseudomonas aeruginosa clinical isolates was 72.6%. Among our isolates, 78.8% were Klebsiella pneumoniae. The most frequently detected carbapenemase genes were blaNDM in 70.0% isolates, followed by blaOXA-48 in 67.6% and blaKPC in 16.5% isolates. CZA active against 30.0% of isolates Conclusion: multiplex PCR is sensitive and specific method for carbapenamase detection. CZA exhibited a fairly susceptible rate among our CRO
530 _aIssued also as CD
653 _aAvibactam
653 _aCeftazidime
653 _aCRO
700 0 _aAmal Mohamed Sayed ,
_eSupervisor
700 0 _aDoaa Mohammad Ghaith ,
_eSupervisor
700 0 _aMona Mohieeden Abdelhaleem ,
_eSupervisor
856 _uhttp://172.23.153.220/th.pdf
905 _aAmira
_eCataloger
905 _aNazla
_eRevisor
942 _2ddc
_cTH
999 _c83767
_d83767