| 000 | 03191cam a2200349 a 4500 | ||
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| 003 | EG-GiCUC | ||
| 005 | 20250223032907.0 | ||
| 008 | 220102s2021 ua dh f m 000 0 eng d | ||
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_aEG-GiCUC _beng _cEG-GiCUC |
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| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.11.28.M.Sc.2021.Ma.S | ||
| 100 | 0 | _aMarina Ezzat Farouk Naguib | |
| 245 | 1 | 0 |
_aSerum vitamin E status in children with idiopathic nephritic syndrome / _cMarina Ezzat Farouk Naguib ; Supervised Mervat Haroun , Amr Mohamed Salem , Rasha Mohamed Helmy Elkaffas |
| 246 | 1 | 5 | _aقياس نسبة فيتامين (هـ) عند الاطفال التى تعانى من المتلازمة الكلوية |
| 260 |
_aCairo : _bMarina Ezzat Farouk Naguib , _c2021 |
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| 300 |
_a98 P. : _bcharts , facsimiles ; _c25cm |
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| 502 | _aThesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics | ||
| 520 | _aObjective:Nephrotic syndrome (NS) is one of the most common chronic kidney diseases in childhood defined by massive proteinuria (greater than 40 mg/m2/hour) responsible for hypoalbuminemia (less than 30 g/l), with resulting hyperlipidemia, edema, and various complications,in recent years,it has been proposed that nephrotic syndrome is a result from imbalance between oxidants and antioxidants. It can be stated that lipid peroxidation is one of the possible cause of nephrotic syndrome progression. Vitamin E acts as a lipid-soluble antioxidant, vitamin E and its various metabolites demonstrate the ability to regulate cellular signaling and gene transcription modulation and act as indirect marker of free radical injury in the body. Methods: The study was a hospital based, prospective cohort study ,aimed to measure serum vitamin E level in 30 consecutive cases of children with nephrotic syndrome during the proteinuric phase of the disease and at 4 weeks after remission was induced by steroid therapy , done by Enzyme-linked immunosorbent assay (ELISA) using commercial kit.Results: The present study revealed highly statistically significant difference between Serum vitamin E level during relapse with Mean ± SD 1.08 ± 0.31 and serum vitamin E level after relapse with Mean ± SD 1.62 ± 0.76 and P value 0.000 in addition, there was highly statistically significant difference found between serum vitamin E level (control group) Mean ± SD 2.43 ± 1.26 and serum vitamin E level during relapse and after relapse in (patient group) with P value 0.004.Conclusion: Vitamin E was active in performing the antioxidant function as indicated by significant depression in its level during the acute pahse followed by partial recovery during remission , it may be concluded that nephrotic syndrome in children is associated with oxidative stress | ||
| 530 | _aIssued also as CD | ||
| 653 | 4 | _aChildren | |
| 653 | 4 | _aIdiopathic nephritic syndrome | |
| 653 | 4 | _aVitamin E | |
| 700 | 0 |
_aAmr Mohamed Salem , _eSupervisor |
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| 700 | 0 |
_aMervat Haroun , _eSupervisor |
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| 700 | 0 |
_aRasha Mohamed Helmy Elkaffas , _eSupervisor |
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| 856 | _uhttp://172.23.153.220/th.pdf | ||
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_aNazla _eRevisor |
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| 905 |
_aShimaa _eCataloger |
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| 942 |
_2ddc _cTH |
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| 999 |
_c83790 _d83790 |
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