| 000 | 02479cam a2200361 a 4500 | ||
|---|---|---|---|
| 003 | EG-GiCUC | ||
| 005 | 20250223032922.0 | ||
| 008 | 220220s2022 ua d f m 000 0 eng d | ||
| 040 |
_aEG-GiCUC _beng _cEG-GiCUC |
||
| 041 | 0 | _aeng | |
| 049 | _aDeposite | ||
| 097 | _aM.Sc | ||
| 099 | _aCai01.08.01.M.Sc.2022.Ha.E | ||
| 100 | 0 | _aHager Abdalhamid Mohamed Abdalhamid | |
| 245 | 1 | 0 |
_aEffect of some chemopreventive agents on galactose induced cataract in rats / _cHager Abdalhamid Mohamed Abdalhamid ; Supervised Nermin Abdelhamid Sadik , Noha Ahmed Elboghdady , Nesreen Nabil Omar |
| 246 | 1 | 5 | _aتأثير بعض المواد للوقاية من إعتام العدسة المحدث بالجالاكتوز فى الجرذان |
| 260 |
_aCairo : _bHager Abdalhamid Mohamed Abdalhmid , _c2022 |
||
| 300 |
_a128 P. : _bcharts , facsimiles ; _c25cm |
||
| 502 | _aThesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry | ||
| 520 | _aCataract is the principal cause of blindness.The enzyme, aldose reductase (AR) is a key player in polyol pathway. Buildup of polyols and oxidative stress are the main causes of cataractogenesis. This study investigated the cytoprotective properties of esculetin and idebenone in galactose-induced cataract. Rats were partitioned into four groups each of ten rats. Control group was fed with normal diet; group 2 rats were fed with galactose diet (50%); groups 3, 4 rats were fed with galactose diet concurrently with either esculetin (50 mg/kg BW) or idebenone (100 mg/kg BW), for 20 days.The study revealed that esculetin and idebenone significantly reduced the elevated levels of Bax/Bcl-2 ratio, malondialdehyde, and DNA fragmentation and increased total antioxidant capacity level in lenses compared to the cataract-induced group. Only esculetin decreased AR, galactitol, and advanced glycated end products levels in lenses. Histopathological examinations supported the biochemical findings. Esculetin and idebenone may have chemopreventive effects for sugar cataract | ||
| 530 | _aIssued also as CD | ||
| 650 | 0 | _aGalactose | |
| 653 | 4 | _aAldose reductase | |
| 653 | 4 | _aCataract | |
| 653 | 4 | _aEsculetin | |
| 700 | 0 |
_aNermin Abdelhamid Sadik , _eSupervisor |
|
| 700 | 0 |
_aNesreen Nabil Omar , _eSupervisor |
|
| 700 | 0 |
_aNoha Ahmed Elboghdady , _eSupervisor |
|
| 856 | _uhttp://172.23.153.220/th.pdf | ||
| 905 |
_aNazla _eRevisor |
||
| 905 |
_aShimaa _eCataloger |
||
| 942 |
_2ddc _cTH |
||
| 999 |
_c84271 _d84271 |
||