000			03005nam a2200337 a 4500
003			EG-GiCUC
008			220228s2021 ua h f m 000 0 eng d
040			_aEG-GiCUC _beng _cEG-GiCUC
041	0		_aeng
049			_aDeposite
097			_aM.Sc
099			_aCai01.12.21.M.Sc.2021.As.E
100	0		_aAsmaa Ahmed Abdelkader
245	1	0	_aEvaluation of the efficacy of nitazoxanide and amebazole in treatment of cryptosporidiosis in immunosuppressed mice / _cAsmaa Ahmed Abdelkader ; Supervised Alyaa Ahmed Farid , Neveen Adel Madbouly , Ibrahim Rabae Shalash
246	1	5	_aتقييم فاعلية النيتازوكسانيد والأميبازول فى علاج داء البوغيات الخبيثة فى الفئران المثبطة مناعيا
260			_aCairo : _bAsmaa Ahmed Abdelkader , _c2021
300			_a70 P. : _bcharts , facsimiles ; _c25cm
502			_aThesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology
520			_aCryptosporidium parvum (C. parvum) is an intestinal parasitic infection affecting both immunosuppressed and immunocompetent individuals. Considering the absence of effective treatment against cryptosporidiosis especially in immunodeficient patients, the present study was designed to assess the therapeutic efficacy of secnidazole (SEC) and its combination with nitazoxanide (NTZ) in comparison to single NTZ treatment in relation to the immune status on a murine model of C. parvum infection. The infected groups were administered NTZ, SEC or NTZ-SEC combination for 3 or 5 successive doses. At days 10 and 12, post infection (PI), the mice were sacrificed, and the efficacy of the applied drugs was evaluated by comparing the histopathological alterations in ileum and measuring the T helper (Th1): (Interferon Gamma; IFN-Þ), Th2: (Interleukin (IL)-4 and IL-10) and Th17: (IL-17) cytokine profiles in serum. The NTZ-SEC combination recorded the maximal reduction of C. parvum oocysts shedding, endogenous stages count and intestinal histopathology regardless to the immune status of the infected mice.The efficacy of NTZ-SEC combination was dependent on the period of administration as the 5 days based treatment protocol was more effective than 3 days based one in immunocompetence and immunosuppression as well.The present treatment schedule induced immunomodulatory effect of SEC that develops a protective immune response against C. parvum infection with reduced production of serum IL-17, IFN-Þ, IL-4 and IL-10. Application of NTZ-SEC combined therapy may be useful in treatment of C. parvum especially in case of immunosuppression
530			_aIssued also as CD
650		0	_aZoology
653			_aCryptosporidiosis
653			_aImmunosuppressed
653			_aNitazoxanide
700	0		_aAlyaa Ahmed Farid , _eSupervisor
700	0		_aIbrahim Rabae Shalash , _eSupervisor
700	0		_aNeveen Adel Madbouly , _eSupervisor
905			_aShimaa _eCataloger
905			_eRevisor
942			_2ddc _cTH
999			_c84374 _d84374