000			029650000a22003490004500
003			EG-GICUC
005			20250223033023.0
008			061017s2006 ua a f m 000 0 eng d
040			_aEG-GICUC _beng _cEG-GICUC
041	0		_aEng
049			_aDeposite
097			_aPh.D
099			_aCai01.11.08.Ph.D.2006.Sa.G.
100	0		_aSameera Ezzat AbouElKhair
245	1	0	_aGenetic mutation study among hepatocellular carcinoma patients : _bCase control Study / _cSameera Ezzat AbouElKhair ; Supervised Nargis Albert Labib , Laila Shehata Dorgham , Hussein Mostafa Khaled
246	1	5	_aالتحولات الجينيه لمرضى سرطان الكبد دراسة حالات وعينات ضابطة
260			_aCairo : _bSameera Ezzat AbouElKhair , _c2006
300			_a142P : _bill ; _c30cm
502			_aThesis (PH.D.) - Cairo University - Faculty Of Medicine - Department Of Community Medicine
520			_aHepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwideThe aim of the present study was to assess the association of mutation of specific genes : cytochrome P450 1A1 (CYP1A1) , cytochrome P450 2D6 (CYP2D6) , microsomal epoxide hydrolase (EPHX) and paraoxonase (PON1) and environmental exposures on the risk of HCC in EgyptA case - control study was conducted on 459 subjects with confirmed HCC recruited from the National Cancer Institute , Cairo University , Egypt , and 634 controls recruited from orthopedic department , Cairo University Hospital , Egypt and from two villages in Menoufiya governoratePatients who agreed to participate signed a consent form , answered a questionnaire and gave a blood sample for hepatitis virus and genetic testingPON1 polymorphism was inversely related to HCC , OR was 07 (95in hundred CI : 05 - 11) EPHX1 Slow activity was significantly associated with HCC (OR= 15 , 95in hundred CI : 11 - 22) compared to high metabolizers after adjustment with age , sex , current HCV and current HBV infectionCYP1A1 mutation was not associated with HCC in the present study (OR= 20 , 95in hundred CI : 04 - 102) CYP2D6 extensive metabolizers was associated with HCC (OR= 18 , 95in hundred CI : 11 - 30) compared to poor metabolizersNo significant interaction between smoking or pesticides exposure and the studied genesAs expected , the strongest risk factors for HCC in this study were HCV RNA (OR = 11 - 13) and current HBV infection (OR = 6 - 9) This study therefore suggests that mutation in the studies genes are additive risk factors to current HCV and HBV infection
530			_aIssued also as CD
653		4	_aEnvironment interaction
653		4	_aGene
653		4	_aHepatocellular carcinoma
700	0		_aHussein Mostafa Khaled , _eSupervisor
700	0		_aLaila Shehata Dorgham , _eSupervisor
700	0		_aNargis Albert Labib , _eSupervisor
856			_uhttp://172.23.153.220/th.pdf
905			_aAmira _eCataloger
905			_aEsam _eRevisor
942			_2ddc _cTH
999			_c86294 _d86294