000			020720000a22003130004500
003			EG-GICUC
008			061116s2005 ua a f m 000 0 eng d
040			_aEG-GICUC _beng _cEG-GICUC
041	0		_aEng
049			_aDeposite
097			_aPh.D
099			_aCai01.12.02.Ph.D.2005.Ah.M.
100	0		_aAhmed Anwar Sayed Mohamed
245	1	0	_aMolecular study of multiple tumor suppressor gene and epidermal growth factor receptor expressions in breast carcinomas / _cAhmed Anwar Sayed Mohamed ; Supervised Sanaa Osman Abdallah , Afaf Abd El Halim Abd El Khalek , Motawa Eisa ElHousseini
246	1	5	_aدراسة جزيئيه للتعرف على الجين المتعدد و المثبط و مستقبل عامل النمو الجلدى فى اورام الثدي
260			_aCairo : _bAhmed Anwar Sayed Mohamed , _c2005
300			_a137p : _bill ; _c30cm
502			_aThesis (PH.D.) - Cairo University - Faculty Of Science - Department Of Biochemistry
520			_aexpression has been reported in cancer cell lines and in certain malignant neoplasmThis gene encodes a protein that function as a negative cell cycle regulator at G1 - S checkpointOverexpression of EGFR has been shown in human cancer and could serve as a target for diagnosis and therapy for malignancyThis study was conducted on 14 benign breast tissues taken as control and 36 breast cancer patientsRT - PCR and ELISA techniques were used for detection of p16 and EGFR respectivelyFurthermore a significant increase of p16 expression was observed in benign breast tissue compared to malignant breast one p< 0001Also , a significant increase of p16 expression was found in low grade , negative lymph node and in histological subtype IL{u00B4}ђ{u008ѕ}C
530			_aIssued also as CD
653		4	_aCarcinomas
653		4	_aexpressions
700	0		_aAfaf Abd El Halim Abd El Khalek , _eSupervisor
700	0		_aMotawa Eesa El Housseini , _eSupervisor
700	0		_aSanaa Osman Abdallah , _eSupervisor
905			_aAml _eCataloger
905			_aEsam _eRevisor
942			_2ddc _cTH
999			_c8915 _d8915