Thesis (M.Sc.)-Cairo University, 2024.

Bibliography: pages 200-250.

Background: Sleeping disorders are more common in people with MS than in
healthy people. Sleep deprivation for one-night, chronic low-quality sleep, and
sleep disorders were all found to affect normal healthy adults' postural control and
balance abilities. There is a knowledge gap in understanding the impact of sleep
disorders on physical performance in people with MS and in normal subjects.
Aim of the study: To investigate the effect of sleep disorders on postural control
in patients with remitting-relapsing multiple sclerosis (RRMS).
METHODS: A cross-sectional observational study was conducted on sixty
RRMS patients of both sexes, aged 20 to 40 years, with EDSS scores less than
four and greater than 24, according to the Mini-Mental State Examination Scale
(MMSE). Patients were divided according to the Pittsburgh sleep quality index
(PSQI) into two groups; the sleep disorders group (SD group, n=30, PSQI > 5) and
the non-sleep disorder group (NSD group, n=30, PSQI ≤ 5).
Sleep was assessed using the PSQI and the Epworth sleepiness scale (ESS). In
contrast, postural control was evaluated by the Biodex Balance System by the
dynamic test measurements of overall stability index (SI), anteroposterior stability
index (APSI), mediolateral stability index (MLSI), and Limits of stability (LOS).
Fatigue was assessed using the fatigue severity scale.
Results: There is no significant difference between the two groups in the Epworth
sleepiness scale, overall SI, and the APSI, while there was a substantial difference
in the fatigue severity scale, MLSI, and the LOS in favor of the SD group.
Conclusion: These results revealed that sleeping disorders in RRMS may
negatively affect some aspects of their postural control, mainly mediolateral
stability and limits of stability, and negatively affect fatigue.

أجريت دراسة رصدية مقطعية مستعرضة على ستين مريضا يعانون من التصلب المتعدد الانتكاسي من كلا الجنسين ، تتراوح أعمارهم بين العشرون و الاربعون عاما , مع درجة مقياس حالة الإعاقة الموسع أقل من أربعة . ودرجة أكبر من اربعة وعشرون وفقا لمقياس فحص الحالة العقلية المصغر . تم تقسيم المرضى وفقا لمؤشر جودة النوم في بيتسبرغ إلى مجموعتين. مجموعة اضطرابات النوم (عدد= ثلاثون ، > 5 مؤشر جودة النوم في بيتسبرغ) ، ومجموعة اضطرابات غير النوم (عدد= ثلاثون ، 5 ≤ مؤشر جودة النوم في بيتسبرغ). تم تقييم النوم باستخدام مؤشر جودة النوم في بيتسبرغ ومقياس إيبوورث للنعاس ، بينما تم تقييم التحكم في الوضع من خلال نظام توازن بيودكس من خلال قياسات الاختبار الديناميكي لمؤشر الاستقرار الكلي ومؤشر الاستقرار الأمامي الخلفي ومؤشر الاستقرار المتوسط وحدود الاستقرار. تم تقييم التعب باستخدام مقياس شدة التعب.

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Text in English and abstract in Arabic & English.