Thesis (Ph.D)-Cairo University, 2024.

Bibliography: pages 78-98.

Background and objectives: Vulvovaginal Candidiasis (VVC) is a prevalent infectious disease in women of reproductive age, necessitating effective non-drug therapies. Therefore, this study aimed to investigate the effect of blue light emitting diode (LED) therapy as an alternative treatment for VVC due to its proven antimicrobial properties. The safety and non-invasiveness of LED therapy make it a promising option for sensitive tissue applications. Subjects and Methods: Sixty women with culture-confirmed VVC Participated in this study. They were allocated randomly to two groups. Group A (control group) received standard antifungal treatment with Gynoconazol 0.8% vaginal cream for three consecutive nights (n=30). Group B (study group) received the same antifungal treatment plus two 2 sessions of blue LED therapy directed at the vulva and vagina (30-minutes each), with the sessions separated by two days (n=30). Candida counts (via CHROMagar™️ Candida) and vaginal pH (AD110-AD111 meters) were assessed at baseline and one week after initiating treatment. Results: Post-treatment, group (B) demonstrated a significantly greater reduction in Candida counts compared to group (A) (p < 0.05). However, there was statistically non-significant difference in vaginal pH between groups (p>0.05). Conclusions: Blue LED therapy effectively reduces Candida counts in women with recurrent VVC without adversely affecting the vaginal pH.

يُعرف داء المُبيضات الفرجى المهبلى بالعدوى الفطرية المنتشرة بين النساء في سن الإنجاب، مما يستلزم علاجات فعالة غير دوائية. ولذلك هدفت هذه الدراسة إلى فحص تأثير العلاج بالصمام الباعث للضوء الأزرق كعلاج بديل للعلاج الدوائى لداء المُبيضات الفرجى المهبلى بسبب خصائصه المُثبتة المُضادة للميكروبات، كما أن سلامة العلاج بتقنية الضوء الأزرق وعدم تدخله الجراحي يجعله خيارًا واعدًا لتطبيقات الأنسجة الحساسة

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Text in English and abstract in Arabic & English.