Evaluating the role of molecular polar surface area on cell permeation : A multivariate model / Yasmine Magdy Mandour ; Supervised Stefan Laufer , Raimund Niess , Thomas Scior
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TextLanguage: English Publication details: Cairo : Yasmine Magdy Mandour , 2010Description: 142Leaves : charts , facsimiles ; 30cmOnline resources: Dissertation note: Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry Summary: Recent drug design strategies consider the pharmacokinetic properties of drug candidates at early stages of drug development prior to any clinical trials . For some years , many in silico ADME screens have been developed . Polar surfce area (PSA) has been a very popular descriptor for the prediction of drug absorption . This descriptor seems to encode an optimal combination of hydrogen bonding features , molecular polarity and solubility properties
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Thesis
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قاعة الثقاقات الاجنبية - الدور الثالث | المكتبة المركزبة الجديدة - جامعة القاهرة | Cai01.34.M.Sc.2010.Ya.E (Browse shelf(Opens below)) | Not for loan | 01010110060247000 |
Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry
Recent drug design strategies consider the pharmacokinetic properties of drug candidates at early stages of drug development prior to any clinical trials . For some years , many in silico ADME screens have been developed . Polar surfce area (PSA) has been a very popular descriptor for the prediction of drug absorption . This descriptor seems to encode an optimal combination of hydrogen bonding features , molecular polarity and solubility properties
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