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The role of insulin resistance (HOMA-IR) in the development of hepatocellular carcinoma associated with chronic hepatitis C genotype- 4 infection / Noha Ramadan Elsayed Barhim ; Supervised Abdelgawad M. Hashem , Amal Ahmed Mohamed

By: Contributor(s): Material type: TextLanguage: English Publication details: Cairo : Noha Ramadan Elsayed Barhim , 2014Description: 111 P. : charts , facsimiles ; 25cmOther title:
  • HCV- gentotype فى تطور سرطان الكبد المرتبط - بالالتهاب الكبدى المزمن سى النوع الرابع4 HOMA-IRدور مقاومة الانسولين [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Microbiology and Immunology Summary: HCV is a major cause of chronic hepatitis and HCC. Different HCV genotypes show characteristic variations in their pathological properties. IR occurs early in HCV infection and may synergize with viral hepatitis in HCC development. Egypt has the highest reported rates of HCV infection (predominantly genotype 4) in the world; this study investigated effects of HCV- 4 on prevalence of insulin resistance in CHC and HCC in Egyptian patients. 50 CHC patients, 50 HCC patients and 20 normal subjects were studied. IR was estimated using HOMA-IR index and HCV-4 load was determined using real-time polymerase chain reaction. Hepatitis B virus was excluded by ELISA. Standard laboratory and histopathological investigations were undertaken to characterize liver function and for grading and staging of CHC; HCC staging was undertaken using intraoperative samples
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Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.06.M.Sc.2014.No.R (Browse shelf(Opens below)) Not for loan 01010110065614000
CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.06.M.Sc.2014.No.R (Browse shelf(Opens below)) 65614.CD Not for loan 01020110065614000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Microbiology and Immunology

HCV is a major cause of chronic hepatitis and HCC. Different HCV genotypes show characteristic variations in their pathological properties. IR occurs early in HCV infection and may synergize with viral hepatitis in HCC development. Egypt has the highest reported rates of HCV infection (predominantly genotype 4) in the world; this study investigated effects of HCV- 4 on prevalence of insulin resistance in CHC and HCC in Egyptian patients. 50 CHC patients, 50 HCC patients and 20 normal subjects were studied. IR was estimated using HOMA-IR index and HCV-4 load was determined using real-time polymerase chain reaction. Hepatitis B virus was excluded by ELISA. Standard laboratory and histopathological investigations were undertaken to characterize liver function and for grading and staging of CHC; HCC staging was undertaken using intraoperative samples

Issued also as CD

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