Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Ophthalmology

OBJECTIVE: To monitor the changes in corneal thickness during accelerated pulsed corneal collagen cross-linking procedure by using dextran free riboflavin solution with HPMC in keratoconus patients. MATERIALS AND METHODS: The central corneal thickness measurements were obtained by pachymetry before epithelial removal, after epithelial removal, following the instillation of dextran free riboflavin solution with HPMC for 10{u2009}min, and after 8{u2009}min of pulsed ultraviolet A irradiation (30 mW/cm2 surface irradiance for total treatment of 7.2J/cm2). RESULTS: Twenty eyes of eleven patients with progressive keratoconus (n{u2009}={u2009}20) were included in this study. The mean central pachymetric measurements were 506.8±35æm before epithelial removal, declined to a mean of 474.9 ±40 æm after de-epithelialization of the cornea, declined further to a mean of 445.7 ±31æm following 10{u2009}min instillation of dextran free riboflavin solution with HPMC and 444.65±35æm following 8{u2009}min of pulsed ultraviolet A irradiation to the cornea

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