Thesis (Ph.D.) - Cairo University - Faculty of Physical Therapy - Department of Physical Therapy for Cardiopulmonary and Geriatrics Disorders

Purpose: To examine the correlation between nitric oxide and microcirculation after shock wave therapy in type 2 diabetic foot. Subjects and methods: Forty patients participated in this study. They were divided into two groups. The studied group (thirty patients) with a mean age (50.37+3.61) years , received shock wave (SWT) program (3000 shock, 1000/session, 3 sessions, 2 weeks a part, 0.32mJ/mm2) in addition to oral hypoglycemic drugs. The control group (ten patients) with a mean age( 51.73+ 4.21) years , received only the oral hypoglycemic drugs. Patients were randomly distributed into two groups. The basal mean blood perfusion of the foot was measured by Laser Doppler Flowmetry (LDF) ,nitric oxide (NO) level was measured by spectrophotometric technique and vascular endothelial growth factors (VEGF) was measured by stat fax .at the beginning and after four weeks for both groups . Results: Patients subjected to shock wave therapy and hypoglycemic drugs showed significant improvement in all the measured variables. They showed significant improvement in increasing blood perfusion,(NO),and (VEGF) levels. Moreover, the present result revealed that there was significant positive correlation (0.6) between (NO) and microcirculation. However patients subjected to oral hypoglycemic drugs only ,showed insignificant improvement in the studied variables. Conclusion: There is a strong correlation between nitric oxide and microcirculation after shock wave therapy in type 2 diabetic foot

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