Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Physiology

The effect of erythropoietin hormone in STZ-induced diabetic nephropathy was evaluated in this study with comparing this effect with insulin treatment. 110 albino rats were randomized into 11 groups. Type I DM was induced by STZ injection at day 0 followed by serial measurements of serum glucose , insulin, serum urea , serum creatinine, urinary albumin and creatinine clearance levels in all groups. Type I DM was confirmed at week 1 by elevated serum glucose and reduced serum insulin. The diabetic nephropathy was indentified at the end of week 3 by the elevation in serum urea and creatinine levels with reduced creatinine clearance and the presence of albuminuria. Erythropoietin was given by the dose of I00 IU/kg intraperitoneally. Insulin was injected subcutaneously (S .C.) at a dose of 2U/day. Epo treated animals showed improved renal functions in the form of reduced serum urea , creatinine and urinary albumin levels as well as increased creatinine clearance values

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